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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
CLEC9A is a novel activation C-type lectin-like receptor expressed on BDCA3
+
dendritic cells and a subset of monocytes
Journal of Biological Chemistry, Volume 283, No. 24, Year 2008
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Description
We describe here the first characterization of CLEC9A, a group V C-type lectin-like receptor located in the "Dectin-1 cluster" of related receptors, which are encoded within the natural killer (NK)-gene complex. Expression of human CLEC9A is highly restricted in peripheral blood, being detected only on BDCA3+ dendritic cells and on a small subset of CD14+CD16- monocytes. CLEC9A is expressed at the cell surface as a glycosylated dimer and can mediate endocytosis, but not phagocytosis. CLEC9A possesses a cytoplasmic immunoreceptor tyrosine-based activation-like motif that can recruit Syk kinase, and we demonstrate, using receptor chimeras, that this receptor can induce proinflammatory cytokine production. These data indicate that CLEC9A functions as an activation receptor. © 2008 by The American Society for Biochemistry and Molecular Biology, Inc.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC2562446/bin/supp_283_24_16693__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC2562446/bin/supp_M709923200_Suppdata.pdf
Authors & Co-Authors
Huysamen, Cristal
South Africa, Cape Town
University of Cape Town
Willment, Janet Anne
South Africa, Cape Town
University of Cape Town
Dennehy, Kevin M.
South Africa, Cape Town
University of Cape Town
Brown, Gordon D.A.
South Africa, Cape Town
University of Cape Town
Statistics
Citations: 293
Authors: 4
Affiliations: 1
Identifiers
Doi:
10.1074/jbc.M709923200
ISSN:
00219258
e-ISSN:
1083351X
Research Areas
Genetics And Genomics