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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
GRADE guidelines: 15. Going from evidence to recommendation - Determinants of a recommendation's direction and strength
Journal of Clinical Epidemiology, Volume 66, No. 7, Year 2013
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Description
In the GRADE approach, the strength of a recommendation reflects the extent to which we can be confident that the composite desirable effects of a management strategy outweigh the composite undesirable effects. This article addresses GRADE's approach to determining the direction and strength of a recommendation. The GRADE describes the balance of desirable and undesirable outcomes of interest among alternative management strategies depending on four domains, namely estimates of effect for desirable and undesirable outcomes of interest, confidence in the estimates of effect, estimates of values and preferences, and resource use. Ultimately, guideline panels must use judgment in integrating these factors to make a strong or weak recommendation for or against an intervention. © 2013 Published by Elsevier Inc.
Authors & Co-Authors
Andrews, Jeffrey C.
Unknown Affiliation
Schunëmann, Holger J.
Unknown Affiliation
Oxman, Andrew David
Unknown Affiliation
Pottie, Kevin C.
Unknown Affiliation
Meerpohl, Joerg J.
Unknown Affiliation
Alonso-Coello, Pablo
Unknown Affiliation
Rind, David M.
Unknown Affiliation
Montori, Victor M.
Unknown Affiliation
Brito, Juan Pablo
Unknown Affiliation
Norris, Susan L.
Unknown Affiliation
Elbarbary, Mahmoud
Unknown Affiliation
Post, Piet
Unknown Affiliation
Nasser, Mona
Unknown Affiliation
Shukla, Vijay
Unknown Affiliation
Jaeschke, Roman
Unknown Affiliation
Brožek, Jan L.
Unknown Affiliation
Djulbegović, Benjamin J.
Unknown Affiliation
Gordon, Guyatt H.
Unknown Affiliation
Statistics
Citations: 649
Authors: 18
Affiliations: 17
Identifiers
Doi:
10.1016/j.jclinepi.2013.02.003
ISSN:
08954356
e-ISSN:
18785921
Study Design
Randomised Control Trial