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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Chinese and African Euphorbiaceae plant extracts: Markedly enhancing effect on Epstein-Barr virus-induced transformation
Cancer Letters, Volume 19, No. 2, Year 1983
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Description
Chinese and African Euphorbiaceae plant extracts were shown to have a markedly enhancing effect on Epstein-Barr virus (EBV)-induced transformation of human lymphocytes. When 5 × 105 cord blood lymphocytes were seeded into the semisolid agar medium immediately after EBV exposure, 3-10 times more colonies developed in the presence of the plant extracts at their optimal doses. When a smaller number of 5 × 104 cells were seeded, transformed colonies were also observed in the presence of the plant extracts but not in their absence. All of the colonies picked up from the agar medium were EBV-determined nuclear antigen (EBNA)-positive and showed the typical blastoid morphology. There were no colonies detected in the EBV-uninfected cultures with the extracts, indicating that the virus was required for the promotion by these plant extracts of this lymphocyte transformation. Euphorbiaceae plants are known to be employed as local herbal drugs in southern China and tropical Africa, and the possible role as a co-factor of the plant extracts in the development of nasopharyngeal carcinoma (NPC) and African Burkitt's lymphoma (BL) is discussed. © 1983.
Authors & Co-Authors
Mizuno, Fumio
Japan, Sapporo
Hokkaido University School of Medicine
Koizumi, Shigeki
Japan, Sapporo
Hokkaido University School of Medicine
Osato, Toyoro
Japan, Sapporo
Hokkaido University School of Medicine
Kokwaro, John Ongayo
Kenya, Nairobi
University of Nairobi
Ito, Yohei
Japan, Kyoto
Kyoto University
Statistics
Citations: 37
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1016/0304-3835(83)90155-6
ISSN:
03043835
Research Areas
Cancer