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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Genome-wide analysis of cancer/testis gene expression
Proceedings of the National Academy of Sciences of the United States of America, Volume 105, No. 51, Year 2008
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Description
Cancer/Testis (CT) genes, normally expressed in germ line cells but also activated in a wide range of cancer types, often encode antigens that are immunogenic in cancer patients, and present potential for use as biomarkers and targets for immunotherapy. Using multiple in silico gene expression analysis technologies, including twice the number of expressed sequence tags used in previous studies, we have performed a comprehensive genome-wide survey of expression for a set of 153 previously described CT genes in normal and cancer expression libraries. We find that although they are generally highly expressed in testis, these genes exhibit heterogeneous gene expression profiles, allowing their classification into testis-restricted (39), testis/brain-restricted (14), and a testis-selective (85) group of genes that show additional expression in somatic tissues. The chromosomal distribution of these genes confirmed the previously observed dominance of X chromosome location, with CT-X genes being significantly more testis-restricted than non-X CT. Applying this core classification in a genome-wide survey we identified >30 CT candidate genes; 3 of them, PEPP-2, OTOA, and AKAP4, were confirmed as testis-restricted or testis-selective using RT-PCR, with variable expression frequencies observed in a panel of cancer cell lines. Our classification provides an objective ranking for potential CT genes, which is useful in guiding further identification and characterization of these potentially important diagnostic and therapeutic targets. © 2008 by The National Academy of Sciences of the USA.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC2603434/bin/supp_105_51_20422__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC2603434/bin/0810777105_0810777105SI.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC2603434/bin/0810777105_SD1.xls
https://efashare.b-cdn.net/share/pmc/articles/PMC2603434/bin/0810777105_SD2.xls
https://efashare.b-cdn.net/share/pmc/articles/PMC2603434/bin/0810777105_SD3.xls
https://efashare.b-cdn.net/share/pmc/articles/PMC2603434/bin/0810777105_SD4.xls
https://efashare.b-cdn.net/share/pmc/articles/PMC2603434/bin/0810777105_SD5.xls
https://efashare.b-cdn.net/share/pmc/articles/PMC2603434/bin/0810777105_SD6.xls
https://efashare.b-cdn.net/share/pmc/articles/PMC2603434/bin/0810777105_SD7.xls
Authors & Co-Authors
Hofmann, Oliver M.
United States, Boston
Harvard T.h. Chan School of Public Health
South Africa, Bellville
University of the Western Cape
Caballero, Otàvia Luísa Silva Damas
United States, New York
Memorial Sloan-kettering Cancer Center
Stevenson, Brian J.
Switzerland, Epalinges
Ludwig Institute for Cancer Research Lausanne
Switzerland, Lausanne
Sib Swiss Institute of Bioinformatics
Chen, Yaotseng
United States, New York
Weill Cornell Medicine
Cohen, Tzeela
United States, New York
Memorial Sloan-kettering Cancer Center
Chua, Ramon
United States, New York
Memorial Sloan-kettering Cancer Center
Maher, Christopher A.
South Africa, Bellville
University of the Western Cape
Panji, Sumir
South Africa, Bellville
University of the Western Cape
Schaefer, Ulf
South Africa, Bellville
University of the Western Cape
Kruger, Adele
South Africa, Bellville
University of the Western Cape
Lehvas̈laiho, Minna H.
South Africa, Bellville
University of the Western Cape
Carninci, Piero
Japan, Yokohama
Riken Yokohama Institute
Japan, Wako
Riken
Hayashizaki, Yoshihide
Japan, Yokohama
Riken Yokohama Institute
Japan, Wako
Riken
Jongeneel, Cornelius Victor
Switzerland, Epalinges
Ludwig Institute for Cancer Research Lausanne
Switzerland, Lausanne
Sib Swiss Institute of Bioinformatics
Simpson, Andrew John George
United States, New York
Memorial Sloan-kettering Cancer Center
Old, Lloyd John
United States, New York
Memorial Sloan-kettering Cancer Center
Hide, Winston A.
United States, Boston
Harvard T.h. Chan School of Public Health
South Africa, Bellville
University of the Western Cape
Statistics
Citations: 325
Authors: 17
Affiliations: 8
Identifiers
Doi:
10.1073/pnas.0810777105
ISSN:
00278424
Research Areas
Cancer
Genetics And Genomics
Study Design
Cross Sectional Study
Study Approach
Quantitative