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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Diabetes mellitus and tuberculosis: Pattern of tuberculosis, two-month smear conversion and treatment outcomes in Guangzhou, China
Tropical Medicine and International Health, Volume 18, No. 11, Year 2013
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Description
Objective: There is a high burden of both diabetes (DM) and tuberculosis (TB) in China. We evaluated the association between DM and the pattern of disease, 2-month sputum smear conversion and treatment outcomes of patients with TB in Guangzhou, China. Method: All patients registered with TB from September 2011 to June 2012 were screened for DM and assessed for treatment outcomes in relation to presence or absence of DM and quality of DM control using patient registers, treatment cards and electronic record systems. Results: There were 1589 patients with TB of whom 189 (12%) had DM. Among those with DM, there was a significantly higher proportion of men, persons aged 35 years and older and persons with smear-positive pulmonary tuberculosis (PTB) (P < 0.01). In patients with DM and new smear-positive PTB, there was a higher proportion who had positive sputum smears at 2 months (21.7% vs. 5.6%, RR 3.85, 95%CI 2.24-6.63), who were lost-to-follow-up (5.2% vs. 1.7%, RR 3.23, 95%CI 1.08-9.63) and who failed treatment (10.3% vs. 2.3%, RR 4.46, 95%CI 1.96-10.18) compared with patients who had no DM. There was no significant association between these adverse outcomes and DM control as measured by 2 and 6-month fasting blood glucose. Conclusion: Diabetes mellitus in new smear-positive patients with PTB was associated with failure to sputum smear convert at 2 months and adverse treatment outcomes of loss-to-follow-up and failure. Further research is needed to understand the reasons for these findings and to determine whether the current length of treatment of 6 months is adequate. © 2013 John Wiley & Sons Ltd.
Authors & Co-Authors
Tan, Shouyong
China, Guangzhou
Guangzhou Chest Hospital
Harries, Anthony David
France, Paris
International Union Against Tuberculosis and Lung Disease
United Kingdom, London
London School of Hygiene & Tropical Medicine
Hinderaker, Sven Gudmund
Norway, Bergen
Universitetet I Bergen
Lin, Yan
China, Beijing
China Office
Chen, Xi
China, Beijing
Capital Medical University
China, Beijing
Beijing Chest Hospital, Capital Medical University
Statistics
Citations: 74
Authors: 5
Affiliations: 7
Identifiers
Doi:
10.1111/tmi.12198
ISSN:
13653156
Research Areas
Health System And Policy
Infectious Diseases
Noncommunicable Diseases
Study Design
Cohort Study
Participants Gender
Male