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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The preventive misconception: Experiences from CAPRISA 004
AIDS and Behavior, Volume 18, No. 9, Year 2014
Notification
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Description
Overestimating personal protection afforded by participation in a preventive trial, e.g. harboring a "preventive misconception" (PM), raises theoretical ethical concerns about the adequacy of the informed consent process, behavioral disinhibition, and adherence to prevention interventions. Data from the CAPRISA 004 1 % tenofovir gel trial were utilized to empirically evaluate these concerns. We found it necessary to re-think the current definition of PM during evaluation to distinguish between true misconception and reasonable inferences of protection based on increased access to evidence-based prevention interventions and/or clinical care. There was a significant association between PM and decreased condom use (p < 0.0001) and between PM and likelihood to present with an STI symptom (p = 0.023). There was, however, limited evidence in support of PM representing a lack of meaningful informed consent, or to suggest that it impacts adherence. Moreover, considering current insufficiencies in female-initiated HIV prevention interventions, PM is perhaps of limited concern in microbicide trials. © 2014 Springer Science+Business Media New York.
Authors & Co-Authors
Dellar, Rachael C.
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
Abdool Karim, Quarraisha Abdool
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
United States, New York
Mailman School of Public Health
Mansoor, Leila Essop
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
Grobler, Anneke C.
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
Humphries, Hilton R.
South Africa, Pretoria
Human Sciences Research Council of South Africa
Werner, Lise
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
Ntombela, Fanelisibonge
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
Luthuli, Londiwe
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
Abdool Karim, Salim S.
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
United States, New York
Mailman School of Public Health
Statistics
Citations: 9
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1007/s10461-014-0771-6
ISSN:
10907165
e-ISSN:
15733254
Research Areas
Health System And Policy
Infectious Diseases
Sexual And Reproductive Health
Participants Gender
Female