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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Streptomycin and chloramphenicol resistance genes in Escherichia coli isolates from cattle, pigs, and chicken in Kenya
Microbial Drug Resistance, Volume 13, No. 1, Year 2007
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Description
The aims of this study were to determine the genetic basis of streptomycin and chloramphenicol resistance in 30 Escherichia coli isolates from food animals in Kenya and the role of plasmids in the spread of the resistance. Seven of the 29 streptomycin-resistant isolates harbored both the strA and strB genes. Twenty-one of isolates had the strA, strB, and aadA1 genes. The strA gene was disrupted by a functional trimethoprim gene, dfrA14 in 10 of the 21 isolates harboring the three streptomycin resistance genes. Physical linkage of intact strA and sul2 genes was found in two different plasmids from four isolates. Linkage of cassette-borne aadA1 and dfrA1 genes in class 1 integrons was found in two of the isolates. Chloramphenicol resistance was due to the gene catA1 in all the chloramphenicol resistant isolates. The strB, strA, and catA1 genes were transferable by conjugation and this points to the significance of conjugative resistance plasmids in the spread and persistence of streptomycin and chloramphenicol resistance in food animals in Kenya. © Mary Ann Liebert, Inc.
Authors & Co-Authors
Kikuvi, Gideon Mutie
Kenya, Nairobi
Jomo Kenyatta University of Agriculture and Technology
Schwarz, Stefan
Germany, Neustadt am Rubenberge
Institut Für Tierzucht
Ombui, Jackson Nyarongi
Kenya, Nairobi
University of Nairobi
Mitema, Eric S.
Kenya, Nairobi
University of Nairobi
Kehrenberg, Corinna
Germany, Neustadt am Rubenberge
Institut Für Tierzucht
Statistics
Citations: 49
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1089/mdr.2006.9998
ISSN:
10766294
Research Areas
Food Security
Genetics And Genomics
Study Locations
Kenya