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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Composition and anti-plasmodial activities of essential oils from some Cameroonian medicinal plants
Phytochemistry, Volume 64, No. 7, Year 2003
Notification
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Description
In a search for new plant-derived biologically active compounds against malaria parasites, five essential oils extracted from the Cameroonian plants Xylopia phloiodora, Pachypodanthium confine, Antidesma laciniatum, Xylopia aethiopica, and Hexalobus crispiflorus were evaluated in regard to their anti-plasmodial activity against the W2 strain of Plasmodium falciparum. The oils were obtained from the plants with 0.12, 0.13, 0.18, 0.6 and 0.1% yields (relatively to dried material weight) respectively. Analysis by gas chromatography and mass spectrometry identified mainly terpenoids, among which α-copaene, γ-cadinene, δ-cadinene, α-cadinol, spathulenol and caryophyllene oxide were most commonly found. The five oils were active against Plasmodium falciparum in culture. The most effective was the oil of Hexalobus crispiflorus, with an IC50 of 2 μg/ml. © 2003 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Boyom, Fabrice Fekam
United States, San Francisco
University of California, San Francisco
Ngouana, Vincent
Unknown Affiliation
Amvam-Zollo, Paul Henri
Unknown Affiliation
Menut, Chantal
France, Montpellier
Enscm Ecole Nationale Supérieure de Chimie de Montpellier
Bessiére, Jean Maríe M.
France, Montpellier
Enscm Ecole Nationale Supérieure de Chimie de Montpellier
Gut, Jiří
United States, San Francisco
San Francisco General Hospital and Trauma Center
Rosenthal, Philip Jon
United States, San Francisco
San Francisco General Hospital and Trauma Center
Statistics
Citations: 136
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1016/j.phytochem.2003.08.004
ISSN:
00319422
Research Areas
Infectious Diseases