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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Increased phospholipid transfer protein activity associated with the impaired cellular cholesterol efflux in type 2 diabetic subjects with coronary artery disease
Tohoku Journal of Experimental Medicine, Volume 213, No. 2, Year 2007
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Description
Reverse cholesterol transport (RCT) is the pathway, by which the excess of cholesterol is removed from peripheral cells to the liver. An early step of RCT is the efflux of free cholesterol from cell membranes that is mediated by high-density lipoproteins (HDL). Phospholipid transfer protein (PLTP) transfers phospholipids between apolipoprotein-B-containing lipoproteins (i.e., chylomicrons and very low-density lipoproteins) and HDL. PLTP contributes to the HDL maturation and increases the ability of HDL to extract the cellular cholesterol. It is known that RCT is impaired in type 2 diabetic patients, especially when cardiovascular complication is associated with. In this study, we measured the serum capacity that promotes cellular cholesterol efflux and the plasma PLTP activity in type 2 diabetic patients with coronary artery disease (CAD) (n = 35), those without CAD (n = 24), and 35 healthy subjects as a sex- and age-matched control. In patients with CAD, plasma triglyceride level was higher compared to controls (p < 0.01) and HDL-cholesterol was lower (p < 0.01 vs control and the patients without CAD). In diabetic patients with or without CAD, PLTP activity was consistently increased, compared to controls, while cellular cholesterol efflux activity was decreased by 20% (p < 0.001) or 13.5% (p < 0.01), respectively. In conclusion, plasma PLTP activity was increased in type 2 diabetic patients with or without CAD, which could impair cellular cholesterol removal and might accelerate atherosclerosis in diabetic patients. © 2007 Tohoku University Medical Press.
Authors & Co-Authors
Attia, Nebil
Tunisia, Tunis
University of Carthage
Tunisia, Monastir
Université de Monastir
Nakbi, Amel
Tunisia, Monastir
Université de Monastir
Smaoui, Maha
Tunisia, Monastir
Université de Monastir
Châaba, Raja
Tunisia, Monastir
Université de Monastir
Moulin, Philippe
France, Lyon
Hopital Louis Pradel
Hammami, Sonia Ouali
Tunisia, Monastir
Monastir Hospital
Hamda, Khaldoun Ben
Tunisia, Monastir
Monastir Hospital
Chanussot, Françoise
France, Paris
Inserm
Hammami, M. B.
Tunisia, Monastir
Université de Monastir
Statistics
Citations: 31
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1620/tjem.213.129
ISSN:
00408727
e-ISSN:
13493329
Research Areas
Noncommunicable Diseases
Study Design
Randomised Control Trial
Study Approach
Quantitative