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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Linkage of 'pure' autosomal recessive familial spastic paraplegia to chromosome 8 markers and evidence of genetic locus heterogeneity
Human Molecular Genetics, Volume 3, No. 8, Year 1994
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Description
'Pure' familial spastic paraplegias (FSP) are neuro-degenerative disorders that are clinically characterized by progressive spastlcity of the lower limbs and are inherited as autosomal dominant (DFSP) or autosomal recessive (RFSP) traits. The primary defect in FSP Is unknown. Genetic linkage analysis was applied to five RFSP families from Tunisia. In four of these five families tight linkage of the RFSP locus was established to the chromosome 8 markers, D8S260, D8S166, D8S285, PLAT, and D8S279. The RFSP locus in the fifth family was not linked to these markers which provided evidence of genetic locus heterogeneity In RFSP. Identification of the RFSP gene on chromosome 8 will help in understanding the genetic factors in motor neuron degeneration. © 1994 Oxford University Press.
Authors & Co-Authors
Hentati, A.
United States, Chicago
Northwestern University Feinberg School of Medicine
Tunisia, Tunis
Institut National de Neurologie Mongi-ben Hamida
Kunkle, Brian W.
United States, Durham
Duke University Medical Center
Hung, Wu Yen
United States, Chicago
Northwestern University Feinberg School of Medicine
Belal, Samir
Tunisia, Tunis
Institut National de Neurologie Mongi-ben Hamida
Laing, Nigel G.
Australia, Perth
Queen Elizabeth Ii Medical Centre Trust
Boustany, R. M.
United States, Durham
Duke University Medical Center
Hentatl, F.
Tunisia, Tunis
Institut National de Neurologie Mongi-ben Hamida
Hamlda, M. Ben
Tunisia, Tunis
Institut National de Neurologie Mongi-ben Hamida
Siddique, Teepu S.
United States, Chicago
Northwestern University Feinberg School of Medicine
Statistics
Citations: 137
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1093/hmg/3.8.1263
ISSN:
09646906
Research Areas
Genetics And Genomics
Study Locations
Tunisia