Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Aspirin in patients undergoing noncardiac surgery
New England Journal of Medicine, Volume 370, No. 16, Year 2014
Notification
URL copied to clipboard!
Description
BACKGROUND: There is substantial variability in the perioperative administration of aspirin in patients undergoing noncardiac surgery, both among patients who are already on an aspirin regimen and among those who are not. METHODS: Using a 2-by-2 factorial trial design, we randomly assigned 10,010 patients who were preparing to undergo noncardiac surgery and were at risk for vascular complications to receive aspirin or placebo and clonidine or placebo. The results of the aspirin trial are reported here. The patients were stratified according to whether they had not been taking aspirin before the study (initiation stratum, with 5628 patients) or they were already on an aspirin regimen (continuation stratum, with 4382 patients). Patients started taking aspirin (at a dose of 200 mg) or placebo just before surgery and continued it daily (at a dose of 100 mg) for 30 days in the initiation stratum and for 7 days in the continuation stratum, after which patients resumed their regular aspirin regimen. The primary outcome was a composite of death or nonfatal myocardial infarction at 30 days. RESULTS: The primary outcome occurred in 351 of 4998 patients (7.0%) in the aspirin group and in 355 of 5012 patients (7.1%) in the placebo group (hazard ratio in the aspirin group, 0.99; 95% confidence interval [CI], 0.86 to 1.15; P = 0.92). Major bleeding was more common in the aspirin group than in the placebo group (230 patients [4.6%] vs. 188 patients [3.8%]; hazard ratio, 1.23; 95% CI, 1.01, to 1.49; P = 0.04). The primary and secondary outcome results were similar in the two aspirin strata. CONCLUSIONS: Administration of aspirin before surgery and throughout the early postsurgical period had no significant effect on the rate of a composite of death or nonfatal myocardial infarction but increased the risk of major bleeding. (Funded by the Canadian Institutes of Health Research and others; POISE-2 ClinicalTrials.gov number, NCT01082874.) Copyright © 2014 Massachusetts Medical Society.
Authors & Co-Authors
Devereaux, Philip James
Canada, Hamilton
Hamilton Health Sciences
Canada, Hamilton
Mcmaster University
Mrkobrada, Marko
Canada, Hamilton
Hamilton Health Sciences
Canada, London
London Health Sciences Centre
Sessler, Daniel I.
United States, Cleveland
Cleveland Clinic Foundation
Leslie, Kate E.
Australia, Melbourne
Royal Melbourne Hospital
Alonso-Coello, Pablo
Spain, Hospitalet de Llobregat
Institut D'investigació Biomedica de Bellvitge
Kurz, Andrea M.
United States, Cleveland
Cleveland Clinic Foundation
Villar, Juan Carlos
Colombia, Bucaramanga
Universidad Autónoma de Bucaramanga
Sigamani, Alben
India, Bengaluru
St. John's National Academy of Health Sciences India
Biccard, Bruce Mclure
South Africa, Durban
The Nelson R. Mandela Medical School
Meyhoff, Christian Sylvest
Denmark, Copenhagen
Københavns Universitet
Parlow, Joel L.
Canada, Kingston
Queen’s University
Gordon, Guyatt H.
Canada, Hamilton
Mcmaster University
Robinson, A.
Canada, Hamilton
Hamilton Health Sciences
Garg, Amit X.
Canada, London
Western University
Rodseth, Reitze Nils
South Africa, Durban
The Nelson R. Mandela Medical School
Botto, Fernando
Canada, Hamilton
Hamilton Health Sciences
Argentina, Buenos Aires
Instituto Cardiovascular de Buenos Aires
Lurati Buse, Giovanna A.L.
Canada, Hamilton
Hamilton Health Sciences
Switzerland, Basel
Universitätsspital Basel
Xavier, Denis
India, Bengaluru
St. John's National Academy of Health Sciences India
Chan, Matthew Tak Vai
Hong Kong, Hong Kong
Chinese University of Hong Kong
Tiboni, Maria E.
Canada, Hamilton
Mcmaster University
Cook, Deborah J.
Canada, Hamilton
Mcmaster University
Kumar, Priya A.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Forget, Patrice
Belgium, Brussels
Cliniques Universitaires Saint-luc
Málaga, Germán M.
Peru, Lima
Universidad Peruana Cayetano Heredia
Fleischmann, Edith
Austria, Vienna
Medizinische Universität Wien
Amir, Mohammed A.
Pakistan, Islamabad
Shifa International Hospital
Eikelboom, John W.
Canada, Hamilton
Hamilton Health Sciences
Canada, Hamilton
Mcmaster University
Mizera, Ryszard
Canada, Hamilton
Mcmaster University
Torres, David P.
Chile, Santiago
Clinica Santa Maria
Wang, Chew Yin
Malaysia, Kuala Lumpur
Universiti Malaya
VanHelder, Tomas
Canada, Hamilton
Mcmaster University
Paniagua, Pilar
Spain, Hospitalet de Llobregat
Institut D'investigació Biomedica de Bellvitge
Berwanger, Otávio
Brazil, Sao Paulo
Research Institute - Hospital do Coração Hcor
Srinathan, Sadeesh K.
Canada, Winnipeg
University of Manitoba
Graham, Michelle M.
Canada, Edmonton
University of Alberta
Pasin, Laura
Italy, Milan
Irccs Ospedale San Raffaele
Le Manach, Yannick
Canada, Hamilton
Hamilton Health Sciences
Canada, Hamilton
Mcmaster University
Gao, Peggy
Canada, Hamilton
Hamilton Health Sciences
Pogue, Janice M.
Canada, Hamilton
Hamilton Health Sciences
Canada, Hamilton
Mcmaster University
Whitlock, Richard Paul
Canada, Hamilton
Hamilton Health Sciences
Canada, Hamilton
Mcmaster University
Lamy, Andre L.
Canada, Hamilton
Hamilton Health Sciences
Canada, Hamilton
Mcmaster University
Kearon, Clive
Canada, Hamilton
Mcmaster University
Baigent, Colin
United Kingdom, Oxford
University of Oxford
Chow, Clara Kayei
Australia, Sydney
The University of Sydney
Pettit, Shirley M.
Canada, Hamilton
Hamilton Health Sciences
Chrolavicius, Susan
Canada, Hamilton
Hamilton Health Sciences
Yusuf, Salim N.
Canada, Hamilton
Hamilton Health Sciences
Canada, Hamilton
Mcmaster University
Statistics
Citations: 706
Authors: 47
Affiliations: 28
Identifiers
Doi:
10.1056/NEJMoa1401105
ISSN:
00284793
e-ISSN:
15334406
Research Areas
Environmental
Health System And Policy