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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Comparative analysis on the effect of Lycopersicon esculentum (tomato) in reducing cadmium, mercury and lead accumulation in liver
Food and Chemical Toxicology, Volume 50, No. 6, Year 2012
Notification
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Description
Scope: L. esculentum (tomato) contain compounds with anti-oxidant and anti-inflammatory properties, able to synthesize metal chelating proteins. We examined the ability of fruit extract to protect against mercury (Hg), lead (Pb) and cadmium (Cd) accumulation in the liver. Methods and results: Rats were fed on tomato mixed with rat chow (10% w/w), while Hg (10. ppm), Cd (200. ppm) and Pb (100. ppm) was given in drinking water. Tomato was administered together with the metals (group 2), a week after exposure (group 3) or a week before metal exposure (group 4) for a period of six weeks. The metal accumulations in the liver were determined using AAS. There was a significant (P< 0.05) increase in protection by tomato to Cd and Hg accumulation but not to Pb (P< 0.05) in weeks 2 and 4 for groups 2 and 3. The protective ability was significantly (P< 0.05) increased for Pb in group 4, but was less comparable to Cd and Hg. Conclusion: Tomato reduces uptake while enhancing the elimination of these metals in a time dependent manner. The highest hepatoprotective effect was to Cd followed by Hg and least to Pb. Its administration is beneficial in reducing heavy metal accumulation in the liver. © 2012 Elsevier Ltd.
Authors & Co-Authors
Nwokocha, Chukwuemeka Raphael
Jamaica, Kingston
The University of the West Indies
Nwokocha, Magdalene I.
Jamaica, Kingston
The University of the West Indies
Aneto, Imaria
Nigeria, Enugu
Madonna University
Obi, Joshua
Nigeria, Enugu
Madonna University
Udekweleze, Damian C.
Nigeria, Enugu
Madonna University
Olatunde, Bukola
Nigeria, Enugu
Madonna University
Owu, Daniel Udofia
Nigeria, Calabar
University of Calabar
Iwuala, Moses O.E.
Nigeria, Owerri
Federal University of Technology, Owerri
Statistics
Citations: 50
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1016/j.fct.2012.03.079
ISSN:
02786915
e-ISSN:
18736351
Research Areas
Environmental