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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Abnormal constitutional karyotypes in patients with neuroblastoma: A report of four new cases and review of 47 others in the literature
Cancer Genetics and Cytogenetics, Volume 147, No. 2, Year 2003
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Description
Anomalies of constitutional karyotype, which have led to the discovery of oncogenes and tumor-suppressor genes in embryonal tumors such as retinoblastoma and Wilms tumor, have, until recently, rarely been reported until recently in neuroblastoma. We present four new cases of neuroblastoma associated with (a) a mosaicism for monosomy 22; (b) an 11q interstitial deletion; (c) a pericentric inversion of chromosome 9 at band 9p21; and (d) a Robertsonian translocation t(13;14). These anomalies and 47 others in the literature are worthy of interest, because some are recurrent, involving the same chromosome regions (1p36, 2p23, 3q, 11q23, and 15q), and some anomalies are situated on chromosome regions known to contain genes involved in neuroblastoma development (1p, 2p, 9p, 11q, 16q, and 17q). Chromosome regions 3q and 15q, observed several times, may also contain genes significant for neuroblastoma onset or development. Furthermore, the lack of neuroblastoma in patients with Down syndrome and Klinefelter or triple-X syndromes, together with a probable excess of neuroblastoma in patients with Turner syndrome, suggests that genes of importance for neuroblastoma may map to chromosomes X and 21. A search for genes implicated in neuroblastoma biology should use these data. © 2003 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Satgé, Daniel C.L.
France
Centre Hospitalier, France
Moore, Samuel W.
South Africa, Cape Town
Stellenbosch University, Faculty of Medicine and Health Sciences
Stiller, Charles A.
United Kingdom, Oxford
University of Oxford
Niggli, F. K.
Switzerland, Zurich
Kinderspital Zürich
Pritchard-Jones, Kathy
United Kingdom, London
The Institute of Cancer Research
Bown, Nick
United Kingdom, Newcastle
Institute for Human Genetics
Bénard, Jean
France, Villejuif
Institut de Cancerologie Gustave Roussy
Plantaz, Dominique
France, Grenoble
Centre Hospitalier Universitaire de Grenoble
Statistics
Citations: 46
Authors: 8
Affiliations: 8
Identifiers
Doi:
10.1016/S0165-4608(03)00203-6
ISSN:
01654608
Research Areas
Cancer