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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31
Nature Communications, Volume 4, Article 1627, Year 2013
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Description
Epithelial ovarian cancer (EOC) has a heritable component that remains to be fully characterized. Most identified common susceptibility variants lie in non-protein-coding sequences. We hypothesized that variants in the 3′ untranslated region at putative microRNA (miRNA)-binding sites represent functional targets that influence EOC susceptibility. Here, we evaluate the association between 767 miRNA-related single-nucleotide polymorphisms (miRSNPs) and EOC risk in 18,174 EOC cases and 26,134 controls from 43 studies genotyped through the Collaborative Oncological Gene-environment Study. We identify several miRSNPs associated with invasive serous EOC risk (odds ratio=1.12, P=10-8) mapping to an inversion polymorphism at 17q21.31. Additional genotyping of non-miRSNPs at 17q21.31 reveals stronger signals outside the inversion (P=10-10). Variation at 17q21.31 is associated with neurological diseases, and our collaboration is the first to report an association with EOC susceptibility. An integrated molecular analysis in this region provides evidence for ARHGAP27 and PLEKHM1 as candidate EOC susceptibility genes. © 2013 Macmillan Publishers Limited. All rights reserved.
Authors & Co-Authors
Lawrenson, Kate
United States, Los Angeles
Keck School of Medicine of Usc
Shen, Howard C.
United States, Los Angeles
Keck School of Medicine of Usc
Tyrer, Jonathan P.
United Kingdom, Cambridge
University of Cambridge
Lin, Huiyi
United States, Tampa
Moffitt Cancer Center
Ramus, Susan J.
United States, Los Angeles
Keck School of Medicine of Usc
Lee, Janet M.
United States, Los Angeles
Keck School of Medicine of Usc
Larson, Melissa C.
United States, Rochester
Mayo Clinic
Aben, Katja K.H.
Netherlands, Nijmegen
Radboud University Medical Center
Anton-Culver, Hoda
United States, Irvine
University of California, Irvine
Antonenkova, Natalia Nikolaevna
Unknown Affiliation
Antoniou, Antonis C.
United Kingdom, Cambridge
University of Cambridge
Armasu, Sebastian M.
United States, Rochester
Mayo Clinic
Bacot, François
Canada, Montreal
Université Mcgill
Baglietto, Laura
Australia, East Melbourne
Cancer Council Victoria
Australia, Melbourne
University of Melbourne
Bandera, E. V.
United States, New Brunswick
Rutgers Cancer Institute of new Jersey
Barnholtz-Sloan, Jill S.
United States, Cleveland
Case Western Reserve University
Beckmann, Matthias Wilhelm
Germany, Erlangen
Friedrich-alexander-universität Erlangen-nürnberg
Birrer, Michael J.
United States, Boston
Massachusetts General Hospital
Bogdanova, Natalia Valerijevna
Germany, Hannover
Hannover Medical School
Brinton, Louise Annette
United States, Rockville
National Cancer Institute Nci
Brooks-Wilson, Angela R.
Canada, Vancouver
Canada‘s Michael Smith Genome Sciences Centre
Brown, Robert
United Kingdom, London
Imperial College London
Bützow, Ralf
Finland, Helsinki
Helsinki University Hospital
Cai, Qiuyin
United States, Nashville
Vanderbilt University School of Medicine
Campbell, I. G. G.
Australia, Melbourne
Peter Maccallum Cancer Centre
Australia, Melbourne
University of Melbourne
Chang-Claude, Jenny C.
Germany, Heidelberg
German Cancer Research Center
Chanock, Stephen J.
United States, Rockville
National Cancer Institute Nci
Chenevix-Trench, Georgia
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Cicek, Mine S.
United States, Rochester
Mayo Medical School
Coetzee, Gerhard A.
United States, Los Angeles
University of Southern California
Cook, Linda S.
United States, Albuquerque
The University of new Mexico
Couch, Fergus J.
United States, Rochester
Mayo Clinic
Cramer, Daniel William
United States, Boston
Brigham and Women's Hospital
Cunningham, Julie M.
United States, Rochester
Mayo Clinic
Dansonka-Mieszkowska, Agnieszka
Poland, Warsaw
Maria Sklodowska-curie National Research Institute of Oncology
Doherty, Jennifer Anne
United States, Hanover
Geisel School of Medicine at Dartmouth
Dörk, Thilo
Germany, Hannover
Hannover Medical School
du Bois, Andreas
Germany, Wiesbaden
Dr. Horst Schmidt Klinik Gmbh
Germany, Essen
Kliniken Essen-mitte
Dürst, Matthias
Germany, Jena
Universitätsklinikum Jena Und Medizinische Fakultät
d'Adamo, Adamo P.
United Kingdom, Cambridge
University of Cambridge
Eccles, Diana M.
United Kingdom, Southampton
University Hospital Southampton Nhs Foundation Trust
Edwards, Robert P.
United States, Pittsburgh
Upmc Magee-womens Hospital
Ekici, Arif B.
Germany, Erlangen
Friedrich-alexander-universität Erlangen-nürnberg
Fasching, Peter Andreas
Germany, Erlangen
Friedrich-alexander-universität Erlangen-nürnberg
United States, Los Angeles
University of California, Los Angeles
Flanagan, James M.
United Kingdom, London
Imperial College London
García-Closas, Montserrat
United Kingdom, London
The Institute of Cancer Research
Gentry-Maharaj, Aleksandra
United Kingdom, London
University College London
Giles, Graham G.
Australia, East Melbourne
Cancer Council Victoria
Australia, Melbourne
University of Melbourne
Australia, Clayton
Monash University
Glasspool, Rosalind M.
United Kingdom, Glasgow
Beatson West of Scotland Cancer Centre
Goodman, Marc T.
United States, Los Angeles
Cedars-sinai Medical Center
Gronwald, Jacek
Poland, Szczecin
Pomeranian Medical University in Szczecin
Hall, Per F.L.
Sweden, Stockholm
Karolinska Institutet
Halle, Mari K.
Norway, Bergen
Haukeland Universitetssjukehus
Norway, Bergen
Universitetet I Bergen
Hillemanns, Peter
Germany, Hannover
Hannover Medical School
Hogdall, Claus Kim
Denmark, Copenhagen
Rigshospitalet
Jakubowska, Anna
Poland, Szczecin
Pomeranian Medical University in Szczecin
Jensen, Allan Ostergaard
Denmark, Copenhagen
Kræftens Bekæmpelse
Kalli, Kimberly R.
United States, Rochester
Mayo Clinic
Karlan, Beth Y.
United States, Los Angeles
Cedars-sinai Medical Center
Kelemen, L. E.
Canada, Edmonton
Alberta Health Services
Kiemeney, Lambertus A.L.M.
Netherlands, Nijmegen
Radboud University Medical Center
Canada, Calgary
University of Calgary
Lambrechts, Diether
Japan, Nagoya
Nagoya University Graduate School of Medicine
Belgium, Ghent
Vlaams Instituut Voor Biotechnologie
Le, Nhu D.
Belgium, Leuven
Ku Leuven
Levine, Douglas A.
Canada, Vancouver
British Columbia Cancer Agency
Liang, Dong
United States, New York
Memorial Sloan-kettering Cancer Center
Lissowska, Jolanta
United States, Houston
The University of Texas Md Anderson Cancer Center
Lu, Karen H.
Poland, Warsaw
Maria Sklodowska-curie National Research Institute of Oncology
Lubiński, Jan
Poland, Szczecin
Pomeranian Medical University in Szczecin
Massuger, Leon F.A.G.
United States, Honolulu
University of Hawaiʻi Cancer Center
Matsuo, Keitaro
Japan, Nagoya
Aichi Cancer Center Hospital and Research Institute
McGuire, Valerie M.
Netherlands, Nijmegen
Radboud University Medical Center
McLaughlin, John R.
United States, Stanford
Stanford University School of Medicine
Canada, Toronto
University of Toronto
Menon, Usha
United Kingdom, London
University College London
Modugno, Francesmary
Canada, Toronto
Mount Sinai Hospital of University of Toronto
United States, Pittsburgh
Upmc Hillman Cancer Center
United States, Pittsburgh
University of Pittsburgh
Moysich, Kirsten Barbara
United States, Pittsburgh
University of Pittsburgh School of Medicine
Narod, Steven Alexander
Japan, Nagoya
Aichi Cancer Center Hospital and Research Institute
Ness, Roberta B.
Denmark, Copenhagen
Rigshospitalet
Nevanlinna, Heli A.
Finland, Helsinki
Helsinki University Hospital
Noushmehr, Houtan
United States, Los Angeles
University of Southern California
United States, Houston
University of Texas School of Public Health
Odunsi, Kunle O.
Brazil, Sao Paulo
Universidade de São Paulo
Pejović, Tanja
United States, New York
Memorial Sloan-kettering Cancer Center
United States, Portland
Oregon Health & Science University
Pike, Malcolm C.
United States, Los Angeles
Keck School of Medicine of Usc
United States, Buffalo
Roswell Park Cancer Institute
Poole, Elizabeth M.
Malaysia, Kuala Lumpur
Universiti Malaya
United States, Boston
Harvard Medical School
Renner, Stefan Peter
Germany, Erlangen
Friedrich-alexander-universität Erlangen-nürnberg
Rossing, Mary Anne
United States, New Haven
Yale School of Medicine
United States, Seattle
Fred Hutchinson Cancer Center
Rudolph, Anja
Germany, Heidelberg
German Cancer Research Center
Runnebaum, Ingo Bernhard
Germany, Jena
Universitätsklinikum Jena Und Medizinische Fakultät
Salvesen, Helga Birgitte
Norway, Bergen
Haukeland Universitetssjukehus
Norway, Bergen
Universitetet I Bergen
Severi, Gianluca
Australia, East Melbourne
Cancer Council Victoria
Australia, Melbourne
University of Melbourne
Shu, Xiaoou
United States, Nashville
Vanderbilt University School of Medicine
Shvetsov, Yurii B.
United States, Houston
The University of Texas Md Anderson Cancer Center
Sieh, Weiva
Netherlands, Nijmegen
Radboud University Medical Center
Song, Honglin
United Kingdom, Cambridge
University of Cambridge
Southey, Melissa Caroline
Unknown Affiliation
Stram, Daniel O.
United States, Los Angeles
Keck School of Medicine of Usc
Teo, Soo Hwang
United States, Tampa
University of South Florida, Tampa
Malaysia, Subang Jaya
Cancer Reserach Initiatives Foundation, Malaysia
Terry, Kathryn L.
United States, Boston
Brigham and Women's Hospital
Tessier, Daniel C.
Canada, Montreal
Université Mcgill
Thompson, Pamela J.
United States, Los Angeles
Cedars-sinai Medical Center
Tworoger, Shelley S.
Malaysia, Kuala Lumpur
Universiti Malaya
United States, Boston
Harvard Medical School
VERGOTE, Ignace B.P.
Belgium, Leuven
Ku Leuven– University Hospital Leuven
Vierkant, Robert A.
United States, Rochester
Mayo Clinic
Vincent, Daniel
Canada, Montreal
Université Mcgill
Wang-Gohrke, Shan
United States, Boston
Harvard T.h. Chan School of Public Health
Wentzensen, Nicolas A.
United States, Rockville
National Cancer Institute Nci
Whittemore, Alice S.
Netherlands, Nijmegen
Radboud University Medical Center
Wik, Elisabeth
Norway, Bergen
Haukeland Universitetssjukehus
Norway, Bergen
Universitetet I Bergen
Wilkens, Lynne Ross
United States, Houston
The University of Texas Md Anderson Cancer Center
Winterhoff, Boris J.N.
United States, Durham
Duke University Medical Center
Wu, Anna H.
United States, Los Angeles
Keck School of Medicine of Usc
Xiang, Yongbing
United States, Rochester
Mayo Clinic
Zheng, Wei
United States, Nashville
Vanderbilt University School of Medicine
Ziogas, Argyrios
China, Shanghai
Shanghai Cancer Institute
Phelan, Catherine M.
United States, Tampa
Moffitt Cancer Center
Iversen, Edwin S.
United States, Irvine
University of California, Irvine
Schildkraut, Joellen M.
Germany, Ulm
Universität Ulm
United States, Durham
Duke University
Berchuck, Andrew W.
United States, Durham
Duke Cancer Institute
Fridley, Brooke L.
United States, Durham
Duke Cancer Institute
United States, Kansas City
University of Kansas Medical Center
Goode, Ellen L.
United States, Rochester
Mayo Medical School
Pharoah, Paul D.P.
United Kingdom, Cambridge
University of Cambridge
Germany, Jena
Universitätsklinikum Jena Und Medizinische Fakultät
Monteiro, Alvaro N.A.
United States, Tampa
Moffitt Cancer Center
Sellers, Thomas
United States, Tampa
Moffitt Cancer Center
Gayther, Simon A.
United States, Los Angeles
Keck School of Medicine of Usc
Statistics
Citations: 90
Authors: 123
Affiliations: 84
Identifiers
Doi:
10.1038/ncomms2613
ISSN:
20411723
Research Areas
Cancer
Genetics And Genomics
Study Design
Case-Control Study