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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
environmental science
Assessment of genotoxicity risk in operation room personnel by the alkaline comet assay
Human and Experimental Toxicology, Volume 32, No. 6, Year 2013
Notification
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Description
This study was conducted to evaluate the possible genotoxic effects of waste anesthetic gases. Comet assay was performed on peripheral blood lymphocytes of 60 volunteers: 20 healthy unexposed office workers and 40 operation room (OR) personnel at Tanta University Hospital (Egypt). The exposed personnel were anesthetists (6 females and 7 males), surgeons (10 males), nurses (9 females), and technicians (8 males). The study revealed significantly increased comet parameters (mean comet tail length and mean percentage of DNA in the tail) in peripheral blood lymphocytes of OR personnel in comparison with control individuals. The maximum DNA damage was observed in anesthesia technicians, whereas the nurses showed the least DNA damage. Furthermore, significant difference was observed between smoker and nonsmokerOR personnel in relation to mean comet tail length. However, no significant difference was seen due to age, gender, or duration of exposure. Also, significant increase in mean percentage of tail DNA was observed in smoker individuals of both exposed and control groups. As a conclusion, this study points to the risk of DNA damage in personnel who are exposed to waste anesthetic gases. © 2013 The Author(s).
Authors & Co-Authors
El-Ebiary, Ahmad A.
Egypt, Tanta
Faculty of Medicine
Abuelfadl, Arwa A.
Egypt, Tanta
Faculty of Medicine
Sarhan, Naglaa Ibrahim
Egypt, Tanta
Tanta University
Othman, M. M.
Egypt, Tanta
Tanta University
Statistics
Citations: 20
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1177/0960327111426584
ISSN:
09603271
e-ISSN:
14770903
Research Areas
Genetics And Genomics
Health System And Policy
Study Locations
Egypt
Participants Gender
Female