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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
A new class of anthelmintics effective against drug-resistant nematodes
Nature, Volume 452, No. 7184, Year 2008
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Description
Anthelmintic resistance in human and animal pathogenic helminths has been spreading in prevalence and severity to a point where multidrug resistance against the three major classes of anthelmintics - the benzimidazoles, imidazothiazoles and macrocyclic lactones - has become a global phenomenon in gastrointestinal nematodes of farm animals. Hence, there is an urgent need for an anthelmintic with a new mode of action. Here we report the discovery of the amino-acetonitrile derivatives (AADs) as a new chemical class of synthetic anthelmintics and describe the development of drug candidates that are efficacious against various species of livestock-pathogenic nematodes. These drug candidates seem to have a novel mode of action involving a unique, nematode-specific clade of acetylcholine receptor subunits. The AADs are well tolerated and of low toxicity to mammals, and overcome existing resistances to the currently available anthelmintics. ©2008 Nature Publishing Group.
Authors & Co-Authors
Kaminsky, Ronald
Switzerland, Saint-aubin
Novartis Centre de Recherche Santé Animale sa
Ducray, Pierre
Switzerland, Basel
Novartis International ag
Jung, Martin
Switzerland, Saint-aubin
Novartis Centre de Recherche Santé Animale sa
Clover, Ralph
United States, Woburn
Cambria Pharmaceuticals, Inc.
Rufener, Lucien
Switzerland, Saint-aubin
Novartis Centre de Recherche Santé Animale sa
Switzerland, Bern
University of Bern
Bouvier, Jacques
Switzerland, Saint-aubin
Novartis Centre de Recherche Santé Animale sa
Weber, Sandra Schorderet
Switzerland, Saint-aubin
Novartis Centre de Recherche Santé Animale sa
Wenger, Andre
Switzerland, Saint-aubin
Novartis Centre de Recherche Santé Animale sa
Wieland-Berghausen, Susanne
Switzerland, Basel
Novartis International ag
Goebel, Thomas
Switzerland, Basel
Novartis International ag
Gauvry, Noelle
Switzerland, Basel
Novartis International ag
Pautrat, François
Switzerland, Basel
Novartis International ag
Skripsky, Thomas
Switzerland, Basel
Novartis International ag
Froelich, Olivier
Switzerland, Saint-aubin
Novartis Centre de Recherche Santé Animale sa
Komoin-Oka, C.
Cote D'ivoire, Lanada
Laboratoire Central Veterinaire de Bingerville
Westlund, Bethany
United States, Woburn
Cambria Pharmaceuticals, Inc.
Sluder, Ann
United States, Woburn
Cambria Pharmaceuticals, Inc.
Mäser, Pascal
Switzerland, Bern
University of Bern
Statistics
Citations: 493
Authors: 18
Affiliations: 5
Identifiers
Doi:
10.1038/nature06722
ISSN:
00280836
e-ISSN:
14764687
Study Design
Cross Sectional Study