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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
G protein β3 subunit gene C825T and angiotensin converting enzyme gene insertion/deletion polymorphisms in hypertensive Tunisian population
Clinical Laboratory, Volume 59, No. 1-2, Year 2013
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Description
Background: We investigated the interaction between the G protein β3 subunit (GNB3) C825T variant and angiotensin converting enzyme (ACE) Insertion/Deletion (I/D) polymorphism in hypertensive Tunisian population. Methods: Analyses of ACE and GNB3 genotypes were performed in 388 hypertensive patients and 425 healthy controls by polymerase chain reaction-restriction fragment length polymorphism. The plasma ACE activity was determined by a spectrophotometric method. Results: The ACE genotype distribution and allele frequencies were not significantly different between the hypertensive and normotensive subjects (p > 0.05). This polymorphism was not associated with hypertension (HTA) (OR = 0.93, 95% CI = 0.75 - 1.15; p = 0.50). In cases, subjects carrying the DD genotype exhibited higher plasma ACE activity than those with ID and II genotypes (p = 0.001). In this group, a linear regression analysis revealed that the ACE I/D polymorphism is independently associated with plasma ACE activity (p = 0.017). The genotypic distribution and allelic frequencies of the GNB3 C825T polymorphism were not significantly different between the two groups. This polymorphism was found to have no effect on the risk of HTA (OR = 1.14, 95% CI = 0.93 - 1.39; p = 0.21). We did not observe a significant interaction between the GNB3 gene and the ACE gene with HTA. Conclusions: In this study, the I/D polymorphism is a significant independent predictor for variability of plasma ACE activity but the ACE I/D and GNB3 C825T polymorphisms are not significant factors for HTA in the Tunisian population. Moreover, we found no interaction between ACE D allele and GNB3 825T allele solely or combined with respect to HTA in the Tunisian population. ©Copyright.
Authors & Co-Authors
Kabadou, Ilhem Ayadi
Tunisia, Tunis
Hôpital la Rabta
Soualmia, Hayet
Tunisia, Tunis
Hôpital la Rabta
Tunisia, Tunis
Institut Supérieur Des Technologies Médicales de Tunis
Jemaa, Riadh
Tunisia, Tunis
Hôpital la Rabta
Feki, Moncef
Tunisia, Tunis
Hôpital la Rabta
Kallel, Amani
Tunisia, Tunis
Hôpital la Rabta
Souheil, Omar
Tunisia, Tunis
Hôpital la Rabta
Taieb, Samah Haj
Tunisia, Tunis
Hôpital la Rabta
Sanhaji, Haïfa
Tunisia, Tunis
Hôpital la Rabta
Kâabachi, Naziha
Tunisia, Tunis
Hôpital la Rabta
Statistics
Citations: 21
Authors: 9
Affiliations: 2
Identifiers
Doi:
10.7754/Clin.Lab.2013.111105
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative