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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Unique acquisition of cytotoxic T-lymphocyte escape mutants in infant human immunodeficiency virus type 1 infection
Journal of Virology, Volume 79, No. 18, Year 2005
Notification
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Description
The role of cytotoxic T-lymphocyte (CTL) escape in rapidly progressive infant human immunodeficiency virus type 1 (HIV-1) infection is undefined. The data presented here demonstrate that infant HIV-1-specific CTL can select for viral escape variants very early in life. These variants, furthermore, may be selected specifically in the infant, despite the same CTL specificity being present in the mother. Additionally, pediatric CTL activity may be compromised both by the transmission of maternal escape variants and by mother-to-child transmission of escape variants that originally arose in the father. The unique acquisition of these CTL escape forms may help to explain the severe nature of some pediatric HIV infections. Copyright © 2005, American Society for Microbiology. All Rights Reserved.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC1212591/bin/jvirol_79_18_12100__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC1212591/bin/jvirol_79_18_12100__ONLINE_SUPPLEMENTAL_MATER.doc
Authors & Co-Authors
Pillay, Thillagavathie
United Kingdom, Oxford
John Radcliffe Hospital
Zhang, Huatang
United Kingdom, Oxford
John Radcliffe Hospital
Drijfhout, Jan Wouter
Netherlands, Leiden
Leids Universitair Medisch Centrum
Robinson, Nicola
United Kingdom, Oxford
John Radcliffe Hospital
Brown, Helen L.
United Kingdom, Oxford
John Radcliffe Hospital
Khan, Munira
South Africa, Durban
The Nelson R. Mandela Medical School
Moodley, Jagdisea M.
South Africa, Durban
The Nelson R. Mandela Medical School
Adhikari, Mirriam A.
South Africa, Durban
The Nelson R. Mandela Medical School
Pfafferott, Katja J.
United Kingdom, Oxford
John Radcliffe Hospital
Feeney, Margaret E.
United States, Boston
Massachusetts General Hospital
St.John, M. Anne
Barbados, Bridgetown
Queen Elizabeth Hospital Bridgetown
Holmes, Edward C.
United Kingdom, Oxford
University of Oxford
Coovadia, Hoosen Mahomed
South Africa, Durban
University of Kwazulu-natal
Klenerman, Paul
United Kingdom, Oxford
John Radcliffe Hospital
Goulder, Philip Jeremy Renshaw
United Kingdom, Oxford
John Radcliffe Hospital
Phillips, Rodney E.
United Kingdom, Oxford
John Radcliffe Hospital
United Kingdom, Oxford
Nuffield Department of Medicine
Statistics
Citations: 49
Authors: 16
Affiliations: 8
Identifiers
Doi:
10.1128/JVI.79.18.12100-12105.2005
ISSN:
0022538X
Research Areas
Infectious Diseases
Maternal And Child Health