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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Alcohol-Metabolizing Enzyme Gene Polymorphisms in the Basque Country, Morocco, and Ecuador
Alcoholism: Clinical and Experimental Research, Volume 35, No. 5, Year 2011
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Description
Background: Genes ADH1B and ADH1C have certain functional SNPs that are related to alcoholism. The frequencies of these polymorphisms vary between populations, so studying them in populations made up of groups with different phylogeographic origins requires an individualized analysis of each group. In the Basque Country, various recently arrived foreign groups live side by side with the original Southern European population, particularly North Africans from Morocco and Hispanics from Ecuador. This study sets out to examine the distribution of the frequencies of alleles that encode alcohol dehydrogenase with different metabolization rates, as higher rates make for greater susceptibility to alcoholism. Methods: Four SNPs: rs1229984, rs2066702, rs698, and rs1693482 using Taqman technology with a Rt-PCR were studied in a sample of 114 European individuals originating from the Basque Country, 100 North Africans from Morocco, and 109 Hispanics from Ecuador. The allele and genotype frequencies were calculated using Genepop v4.0. The most frequent haplotypes were estimated using the ELB algorithm with Arlequin v3.01. A breakdown of the complete disequilibrium commonly observed between the 2 missense polymorphisms that distinguish the common ADH1C alleles rs698 and rs1693482 was observed and confirmed by sequencing in 2 individuals from the Basque Country. Results: A higher frequency of protective allele ADH1C *1 was found in the North African population group. Haplotype combinations are also studied, and the rare association of alleles ADH1B *2-ADH1C *2 was observed in the Southern European group in the Basque Country, along with an allele not hitherto described in the ADH1C locus. Conclusions: This study provides the first data published on the allele and genotype frequencies of the ADH1C locus in the Moroccan population and on the ADH1B and ADH1C loci in the Ecuadorian population. The study shows differences in the distribution of the frequency of allele ADH1C *1 between the Basque Country and Moroccan populations, and a new allele not described to date. Copyright © 2011 by the Research Society on Alcoholism.
Authors & Co-Authors
Celorrio, David
Spain, Leioa
Universidad Del Pais Vasco
Bujanda, Luis
Spain, Leioa
Universidad Del Pais Vasco
Chbel, Faiza
Morocco, Casablanca
Laboratoire de Police Scientifique
Sánchez, Dora
Ecuador, Quito
Hospital Metropolitano
Martínez-Jarreta, Begoña
Spain, Zaragoza
Facultad de Medicina, Universidad de Zaragoza
de Pancorbo, M. M.
Spain, Leioa
Universidad Del Pais Vasco
Statistics
Citations: 10
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1111/j.1530-0277.2010.01418.x
ISSN:
01456008
e-ISSN:
15300277
Research Areas
Genetics And Genomics
Substance Abuse
Study Design
Cross Sectional Study
Study Locations
Morocco