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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Male infertility related to an aberrant karyotype, 47,XYY: Four case reports
Cases Journal, Volume 2, No. 1, Article 28, Year 2009
Notification
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Description
Background: 47,XYY syndrome is a sex chromosomal abnormality observed in humans, with a prevalence of 0.1% of male births. Sex chromosome anomalies are more frequently associated with male infertility. Case report: We present here four cases of infertile men with azoospermia or severe oligozoospermia attending a genetic and fertility clinic. Chromosomal analysis of the peripheral blood lymphocytes demonstrated the constitutional karyotype of 47, XYY. Using fluorescence in situ hybridization (FISH) the presence of extra Y chromosome was confirmed, supporting the cytogenetic finding. Conclusion: The 47,XYY syndrome is relatively uncommon and can be missed clinically because of its variable clinical presentations. Accurate diagnosis of this constitutional karyotype provides a valuable aid in the counselling and early management of the patients who undertake fertility evaluation. © 2009 El-Dahtory and Elsheikha; licensee BioMed Central Ltd.
Authors & Co-Authors
El-Dahtory, Faeza Abdel Mogib
Egypt, Mansoura
Faculty of Medicine
Elsheikha, Hany M.
United Kingdom, Nottingham
University of Nottingham, Faculty of Medicine and Health Sciences
Statistics
Citations: 41
Authors: 2
Affiliations: 2
Identifiers
Doi:
10.1186/1757-1626-2-28
ISSN:
17571626
Research Areas
Genetics And Genomics
Health System And Policy
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Participants Gender
Male