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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Complement C3 plays an essential role in the control of opportunistic fungal infections
Infection and Immunity, Volume 77, No. 9, Year 2009
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Description
The innate recognition of fungal pathogens is a crucial first step in the induction of protective antifungal immunity. Complement is thought to be one key component in this process, facilitating fungal recognition and inducing early inflammation. However, the roles of the individual complement components have not been examined extensively. Here we have used mice lacking C3 to examine its role in immunity to opportunistic fungal pathogens and show that this complement component is essential for resistance to infections with Candida albicans and Candida glabrata. We demonstrate that the absence of C3 impairs fungal clearance but does not affect inflammatory responses. We also show that the presence of C3 contributes to mortality in mice challenged with very high doses of Saccharomyces cerevisiae, although these effects were found to be mouse strain dependent. Copyright © 2009, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Tsoni, Stavroula Vicky
South Africa, Cape Town
University of Cape Town
Kerrigan, Ann M.
South Africa, Cape Town
University of Cape Town
Marakalala, Mohlopheni Jackson
South Africa, Cape Town
University of Cape Town
Srinivasan, Naren
South Africa, Cape Town
University of Cape Town
Duffield, Maureen Susan
South Africa, Cape Town
University of Cape Town
Taylor, Philip Russel
United Kingdom, Cardiff
Cardiff University School of Medicine
Botto, Marina B.
United Kingdom, London
Imperial College London
Steele, Chad
United States, Birmingham
The University of Alabama at Birmingham
Brown, Gordon D.A.
South Africa, Cape Town
University of Cape Town
United Kingdom, Aberdeen
University of Aberdeen School of Medicine, Medical Sciences and Nutrition
Statistics
Citations: 78
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1128/IAI.00233-09
ISSN:
00199567
e-ISSN:
10985522