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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Variants of the mannose-binding lectin gene in the benin population: Heterozygosity for the p.G57E allele may confer a selective advantage
Human Biology, Volume 81, No. 5-6, Year 2009
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Description
Human mannose-binding lectin (MBL) plays an important role in innate immunity. MBL deficiency is associated with mutations in the promoter region and in exon 1 of the MBL2 gene. Such deficiency has been correlated with elevated incidence of infections in infancy and in immunocompromised adults. We determined the distribution profile of the MBL2 gene variants in the general population of Benin (West Africa) and in a vulnerable subset of children with sickle cell disease (SCD) (SS homozygotes). Five hundred forty-two healthy individuals (274 newborns, 268 adults) and 128 patients with SCD (35 newborns, 93 children) were screened for the common variant alleles in the MBL2 secretor haplotype region (exon 1 and promoter). The p.G57E variant allele was the most frequent allele compared to p.G54D (27.5% vs. 1.6%, respectively). The p.R52C allele was not found in this population. There was no difference in allele or genotype frequencies between healthy newborns and newborns with SCD. Alleles associated with MBL deficiency were more frequent in adults than in newborns (69.8% vs. 57.3%, respectively; p = 0.002). This enrichment was exclusively due to an elevated proportion of heterozygotes for the p.G57E allele (47.0% vs. 35.3%, respectively; p = 0.004), supporting a potential selective advantage of this genotype. Our results, compared to those reported in other African countries, support the implication of the MBL2 gene in various major infections in Africa, such as meningitis and tuberculosis in HIV-positive patients. © 2007 Wayne State University Press.
Authors & Co-Authors
Dossou-Yovo, Omer Placide
France, Paris
Hôpital Robert-debré Ap-hp
France, Paris
Université Paris Cité
Benin, Cotonou
University of Abomey-calavi
Lapouméroulie, Claudine L.
France, Paris
Hôpital Robert-debré Ap-hp
France, Paris
Université Paris Cité
Hauchecorne, Michelle
France, Paris
Hôpital Robert-debré Ap-hp
France, Paris
Université Paris Cité
Zaccaria, Isabelle
France, Paris
Inserm
France, Paris
Hôpital Robert-debré Ap-hp
Ducrocq, Rolande
France, Paris
Hôpital Robert-debré Ap-hp
France, Paris
Université Paris Cité
Krishnamoorthy, Rajagopal
France, Paris
Hôpital Robert-debré Ap-hp
France, Paris
Université Paris Cité
Rahimy, Mohamed Cheŕif
Benin, Cotonou
University of Abomey-calavi
Elion, Jacques
France, Paris
Hôpital Robert-debré Ap-hp
France, Paris
Université Paris Cité
Statistics
Citations: 15
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.3378/027.081.0630
ISSN:
00187143
e-ISSN:
15346617
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Multi-countries
Benin