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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Effect of physical exercise on bone density and remodeling in Egyptian type 1 diabetic osteopenic adolescents
Diabetology and Metabolic Syndrome, Volume 3, No. 1, Article 25, Year 2011
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Description
Background: The study was planned to assess effect of physical exercise on bone remodeling in type I diabetics with osteopenia. Methods. Twenty-four type I diabetes mellitus (DM1) with osteopenia (10 females and 14 males) were compared to thirty-eight age- and sex-matched healthy control individuals (20 females and 18 males) for biochemical and radiologic parameters of bone mass. Laboratory investigations included serum and urinary calcium, inorganic phosphorus, alkaline phosphatase, and serum "procollagen type 1 N-terminal propeptide (P1NP). Bone densitometry was assessed at neck femur using Dual Energy X-ray Absorptiometry (DEXA). Serum P1NP and DEXA were reevaluated after a planned exercise program. Results: Patients and controls were comparable with respect to serum as well as urinary biochemical parameters of bone mass namely; calcium, phosphorus and total serum alkaline phosphatase. Osteopenic DM1 patients displayed lower mean serum P1NP than control group (20.11 6.72 ug\dL versus 64.96 34.89 ug\dL; p < 0.05). A significant correlation was observed between BMD and degree of glycemic control reflected by serum glycated hemoglobin (r = -0.44, p, 0.030). Bone densitometry correlated with serum P1NP (r = -0.508, p, 0.011). After a planned regular exercise for 3 months, serum P1NP and BMD levels increased with percentage change of 40.88 31.73 and 3.36 2.94, respectively. Five patients resumed normal densitometry and they were all males. Conclusion: Diabetic osteopenic patients displayed lower serum levels of procollagen type 1 N-terminal propeptide which reflects poor bone formation. A 3-months planned exercise program was associated with improvement of bone densitometry and significant increment of serum P1NP. © 2011 Elhabashy et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Elhabashy, Safinaz Adel
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Said, Omaima
Egypt, Giza
National Research Centre
Agaibyi, Mervat Harvi
Egypt, Giza
National Research Centre
Abdelrazek, Amr A.
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Abdelhamid, Sayed
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Statistics
Citations: 11
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1186/1758-5996-3-25
e-ISSN:
17585996
Research Areas
Noncommunicable Diseases
Study Design
Randomised Control Trial
Participants Gender
Female