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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Prevalence and type distribution of human papillomavirus among 1813 men in Tanzania and the relationship to HIV status
Sexually Transmitted Diseases, Volume 40, No. 7, Year 2013
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Description
Background: Infection with high-risk (HR) human papillomavirus (HPV) is associated with penile cancer in men, cervical cancer in women, and anal cancer and certain types of head and neck cancers in both sexes. Few studies have assessed the prevalence and type distribution of HPV among men in sub-Saharan Africa, where the rates of HIVand penile and cervical cancer are high. Material and Methods: We used data from a cross-sectional study among 1813 men in Tanzania. Penile samples were tested using Hybrid Capture 2, and genotyping was done by the INNO-LiPA HPVGenotyping Extra test. Blood samples were tested for HIV. The overall and type-specific prevalence and 95% confidence interval of HPV was estimated in relation to age and HIV status. Results: The overall prevalence of HPV was 20.5% (95% confidence interval, 18.7-22.4), the most prevalent HR HPV types being HPV52, HPV51, HPV16, HPV18, HPV35, and HPV66. The HR HPV prevalence was significantly higher in HIV-positive men (25.7%) than in HIVnegative men (15.8%; P = 0.0027). The prevalence of HPV16, HPV18 and multiple HR HPVs tended to be higher among HIV-positive men (statistically nonsignificant), whereas no differences were observed for the other HPV types. Conclusions: We found a high prevalence of HPV types 52, 51, 16, 18, 35, and 66. This information is of relevance in the understanding of HPV type distributions across populations. Although the prevalence of HPV16 and HPV18 was slightly higher among HIV-positive men, our results indicate that HIV status does not strongly influence the distribution of HPV types. Therefore, the currently available HPV vaccines could prevent HPV infection independently of HIV status. Copyright © 2013 by the American Sexually Transmitted Diseases Association.
Authors & Co-Authors
Olesen, Tina Bech
Denmark, Copenhagen
Kræftens Bekæmpelse
Iftner, Thomas
Unknown Affiliation
Mwaiselage, Julius David
Tanzania, Dar es Salaam
Division of Cancer Prevention
Kahesa, Crispin
Tanzania, Dar es Salaam
Division of Cancer Prevention
Rasch, Vibeke
Denmark, Odense
Odense Universitetshospital
Ngoma, Twalib Athumani
Tanzania, Dar es Salaam
Division of Cancer Prevention
Munk, Christian
Denmark, Copenhagen
Kræftens Bekæmpelse
Kjaer, Susanne Krûger
Denmark, Copenhagen
Kræftens Bekæmpelse
Denmark, Copenhagen
Københavns Universitet
Statistics
Citations: 17
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1097/OLQ.0b013e31828fcf57
ISSN:
01485717
e-ISSN:
15374521
Research Areas
Cancer
Infectious Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Tanzania
Participants Gender
Male
Female