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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Immunoproteomic discovery of novel T cell antigens from the obligate intracellular pathogen Chlamydia
Journal of Immunology, Volume 180, No. 4, Year 2008
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Description
Chlamydia infections cause substantial morbidity worldwide and effective prevention will depend on a vaccine. Since Chlamydia immunity is T cell-mediated, a major impediment to developing a molecular vaccine has been the difficulty in identifying relevant T cell Ags. In this study, we used a combination of affinity chromatography and tandem mass spectrometry to identify 13 Chlamydia peptides among 331 self-peptides presented by MHC class II (I-Ab) molecules from bone marrow-derived murine dendritic cells infected with Chlamydia muridarum. These MHC class II-bound peptides were recognized by Chlamydia-specific CD4 T cells harvested from immune mice and adoptive transfer of dendritic cells pulsed ex vivo with the peptides partially protected mice against intranasal and genital tract Chlamydia infection. The results provide evidence for lead vaccine candidates for a T cell-based subunit molecular vaccine against Chlamydia infection suitable for human study. Copyright © 2008 by The American Association of Immunologists, Inc.
Authors & Co-Authors
Karunakaran, Karuna P.
Canada, Vancouver
Bc Centre for Disease Control
Rey-Ladino, José A.
Canada, Vancouver
Bc Centre for Disease Control
Shen, Caixia
Canada, Vancouver
Bc Centre for Disease Control
Foster, Leonard J.
Canada, Vancouver
The University of British Columbia
Brunham, Robert C.
Canada, Vancouver
Bc Centre for Disease Control
Statistics
Citations: 100
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.4049/jimmunol.180.4.2459
ISSN:
00221767
Research Areas
Sexual And Reproductive Health