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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Evidence that interferon-γ plays a protective role during cerebral malaria
Journal of Infectious Diseases, Volume 192, No. 5, Year 2005
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Description
Background. The pathogenic mechanisms of cerebral malaria (CM) are unclear but are thought to involve cytokine-mediated inflammation enhanced by parasite sequestration in the brain microcirculation. The role that interferon (IFN)-γ could play that would enhance inflammation but also reduce parasitemia is unclear. Methods. Plasma IFN-γ concentrations were measured by enzyme-linked immunosorbent assay in 96 children with CM and 40 children with uncomplicated malaria (UM) who had been recruited from Gabriel Toure Hospital (Bamako, Mali). We investigated the relationship between IFN-γ concentrations and disease by nonparametric analysis. Polymorphisms in IFNG were characterized by restriction enzyme analysis or size-determination electrophoresis. Associations between polymorphisms and CM were evaluated by the family-based association test on 240 families. Results. During episodes of malaria, IFN-γ concentrations were lower in children with CM than in children with UM (P = .007). IFNG-183T (P = .009) and IFNG-183G/T (P = .013) were found to be less frequent than expected in children with CM. A trend toward association was also observed between IFNG(CA)14/(CA)14 (P = .073) and CM. The IFNG-183G/T and IFNG(CA)14/(CA)14 genotypes were more frequent in children with UM than in children with CM (odds ratio, 0.30 and 0.34, respectively). Conclusions. The low plasma IFN-γ concentrations in children with CM and the associations between a reduced risk of CM and (1) the IFNG-183T allele (which increases gene transcription) and (2) the IFNG-183G/ T genotype are consistent with the concept that IFN-γ protects against CM. © 2005 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Cabantous, Sandrine
France, Marseille
Aix Marseille Université
Poudiougou, Belco
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Traoré, Abdoulaye Mamadou
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Kéita, Mamadou Marouf
Mali, Bamako
Gabriel Toure Hospital
Cissé, Mahamadou Balla
Mali, Bamako
Gabriel Toure Hospital
Doumbo, Ogobara K.
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Dessein, Alain Jacques J.
France, Marseille
Aix Marseille Université
Marquet, Sandrine
France, Marseille
Aix Marseille Université
France, Paris
Inserm
Statistics
Citations: 59
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1086/432484
ISSN:
00221899
Research Areas
Genetics And Genomics
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Case-Control Study
Study Locations
Mali