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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
The influence of human genetic variation on Epstein–Barr virus sequence diversity
Scientific Reports, Volume 11, No. 1, Article 4586, Year 2021
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Description
Epstein–Barr virus (EBV) is one of the most common viruses latently infecting humans. Little is known about the impact of human genetic variation on the large inter-individual differences observed in response to EBV infection. To search for a potential imprint of host genomic variation on the EBV sequence, we jointly analyzed paired viral and human genomic data from 268 HIV-coinfected individuals with CD4 + T cell count < 200/mm3 and elevated EBV viremia. We hypothesized that the reactivated virus circulating in these patients could carry sequence variants acquired during primary EBV infection, thereby providing a snapshot of early adaptation to the pressure exerted on EBV by the individual immune response. We searched for associations between host and pathogen genetic variants, taking into account human and EBV population structure. Our analyses revealed significant associations between human and EBV sequence variation. Three polymorphic regions in the human genome were found to be associated with EBV variation: one at the amino acid level (BRLF1:p.Lys316Glu); and two at the gene level (burden testing of rare variants in BALF5 and BBRF1). Our findings confirm that jointly analyzing host and pathogen genomes can identify sites of genomic interactions, which could help dissect pathogenic mechanisms and suggest new therapeutic avenues. © 2021, The Author(s).
Authors & Co-Authors
Rueger, Sina
Switzerland, Lausanne
École Polytechnique Fédérale de Lausanne
Switzerland, Lausanne
Sib Swiss Institute of Bioinformatics
McLaren, Paul J.
Canada, Ottawa
Public Health Agency of Canada
Canada, Winnipeg
University of Manitoba
Lawless, Dylan
Switzerland, Lausanne
École Polytechnique Fédérale de Lausanne
Switzerland, Lausanne
Sib Swiss Institute of Bioinformatics
Depledge, Daniel Pearce
United Kingdom, London
University College London
Morfopoulou, Sofia
United Kingdom, London
University College London
Breuer, Judith M.
United Kingdom, London
University College London
Zdobnov, Evgeny M.
Switzerland, Lausanne
Sib Swiss Institute of Bioinformatics
Switzerland, Geneva
Université de Genève Faculté de Médecine
Fellay, Jacques
Switzerland, Lausanne
École Polytechnique Fédérale de Lausanne
Switzerland, Lausanne
Sib Swiss Institute of Bioinformatics
Switzerland, Lausanne
Université de Lausanne Unil
Aebi-Popp, Karoline
Switzerland, Bern
University of Bern
Anagnostopoulos, Alexia
Switzerland, Zurich
Universität Zürich
Battegay, Manuel
Switzerland, Basel
Universitat Basel
Bernasconi, Enos
Switzerland, Bellinzona
Ente Ospedaliero Cantonale
Böni, Jürg
Switzerland, Zurich
Universität Zürich
Braun, Dominique Laurent
Switzerland, Zurich
Universität Zürich
Calmy, Alexandra L.
Switzerland, Geneva
Université de Genève
Cavassini, Matthias
Switzerland, Lausanne
Université de Lausanne Unil
Ciuffi, Angela
Switzerland, Lausanne
Université de Lausanne Unil
Dollenmaier, Guenter
Unknown Affiliation
Egger, Matthias
Switzerland, Bern
University of Bern
Elzi, Luigia
Switzerland, Basel
Universitat Basel
Fehr, Jan Sven
Switzerland, Zurich
Universität Zürich
Furrer, Hansjakob Jackob
Switzerland, Bern
University of Bern
Fux, Christoph Andreas
Switzerland, Aarau
Kantonsspital Aarau
Günthard, Huldrych F.
Switzerland, Zurich
Universität Zürich
Haerry, David Hans Ulrich
Unknown Affiliation
Hasse, Barbara Katharina
Switzerland, Zurich
Universität Zürich
Hirsch, Hans H.
Switzerland, Basel
Universitat Basel
Switzerland, Basel
Universitätsspital Basel
Hoffmann, Matthias
Switzerland, St Gallen
Kantonsspital St.gallen
Hösli, Irene Mathilde
Switzerland, Basel
Universitat Basel
Huber, Michael J.
Switzerland, Zurich
Universität Zürich
Kahlert, Christian R.
Switzerland, St Gallen
Kantonsspital St.gallen
Switzerland, St Gallen
Children's Hospital of Eastern Switzerland
Kaiser, Laurent K.
Switzerland, Geneva
Université de Genève
Keiser, Olivia
Switzerland, Geneva
Université de Genève
Klimkait, Thomas
Switzerland, Basel
Universitat Basel
Kouyos, Roger D.
Switzerland, Zurich
Universität Zürich
Kovari, Helen
Switzerland, Zurich
Universität Zürich
Ledergerber, Bruno
Switzerland, Zurich
Universität Zürich
Martinetti, Gladys
Switzerland, Bellinzona
Cantonal Institute of Microbiology
Martínez de Tejada, Begoῆa
Switzerland, Geneva
Université de Genève
Marzolini, Catia
Switzerland, Basel
Universitat Basel
Metzner, Karin Jutta
Switzerland, Zurich
Universität Zürich
Müller, Nicolas J.
Switzerland, Zurich
Universität Zürich
Nicca, Dunja
Switzerland, St Gallen
Kantonsspital St.gallen
Paioni, Paolo
Switzerland, Zurich
Universität Zürich
Pantaleo, Giuseppe P.
Switzerland, Lausanne
Université de Lausanne Unil
Perreau, Matthieu
Switzerland, Lausanne
Université de Lausanne Unil
Rauch, Andri
Switzerland, Bern
University of Bern
Rudin, Christoph
Switzerland, Basel
Universitat Basel
Scherrer, Alexandra U.
Switzerland, Zurich
Universität Zürich
Schmid, Patrick
Switzerland, St Gallen
Kantonsspital St.gallen
Speck, Roberto F.
Switzerland, Zurich
Universität Zürich
Stöckle, Marcel
Unknown Affiliation
Tarr, Philip E.
Switzerland, Basel
Universitat Basel
Trkola, Alexandra
Switzerland, Zurich
Universität Zürich
Vernazza, Pietro Luigi
Switzerland, St Gallen
Kantonsspital St.gallen
Wandeler, Gilles
Switzerland, Bern
University of Bern
Weber, Rainer
Switzerland, Zurich
Universität Zürich
Yerly, Sabine T.B.D.
Switzerland, Geneva
Université de Genève
Statistics
Citations: 6
Authors: 58
Affiliations: 18
Identifiers
Doi:
10.1038/s41598-021-84070-7
ISSN:
20452322
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study