Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Clinical trial of VP 16–213 (NSC 141540) I.V. Twice weekly in advanced neoplastic disease a study by the cancer and leukemia group B
Cancer, Volume 45, No. 2, Year 1980
Notification
URL copied to clipboard!
Description
The epipodophyllotoxin derivative VP 16–213 (NSC 141540) was studied by the Cancer and Leukemia Group B in a broad phase II trial at three dose levels: 60 mg/m2, 90 mg/m2, and 135 mg/m2 I.V. twice weekly. No correlation between dose of VP 16–213 and response frequency in a particular disease category could be demonstrated. Of the 382 patients, 8% obtained a complete (CR) or partial remission (PR), 8% showed improvement, and 14% had stable disease. By tumor type the best responses were obtained in lymphomas (8/31 CR + PR), uterus (2/9), prostate (1/5), rhabdomyosarcoma (2/6), neuroblastoma (2/4), colon/rectum (5/81), other gastrointestinal (4/32). In lung tumors, 4/80 patients obtained CR or PR. VP 16–213 has definite antineoplastic activity but the response frequency with the twice weekly schedule may be lower than that reported with other schedules. Copyright © 1980 American Cancer Society
Authors & Co-Authors
Nissen, Nis Iversen
Denmark, Copenhagen
Finsen Institute
Pajak, Thomas F.
United States, Scarsdale
Calgb
Leone, Louis A.
United States, Providence
Rhode Island Hospital
Bloomfield, Clara Derber
United States, Minneapolis
University of Minnesota Twin Cities
Kennedy, B. J.
United States, Minneapolis
University of Minnesota Twin Cities
Ellison, Rose Ruth
United States, Buffalo
University at Buffalo, the State University of new York
Silver, Richard T.
United States, New York
Weill Cornell Medical Center
Weiss, Raymond B.
United States, Morgantown
West Virginia University School of Medicine Morgantown
Cuttner, Janet
United States, New York
The Mount Sinai Hospital
Falkson, Geoffrey G.
South Africa, Pretoria
Steve Biko Academic Hospital
Kung, Faith H.
United States, La Jolla
University of California, San Diego
Bergevin, Patrick R.
United States, New York
Maimonides Medical Center
Holland, James F.W.
United States, New York
The Mount Sinai Hospital
Statistics
Citations: 66
Authors: 13
Affiliations: 11
Identifiers
Doi:
10.1002/1097-0142(19800115)45:2<232::AID-CNCR2820450206>3.0.CO;2-F
ISSN:
0008543X
e-ISSN:
10970142
Research Areas
Cancer