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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Gag-specific CD4+ T-cell responses are associated with virological control of paediatric HIV-1 infection
AIDS, Volume 25, No. 10, Year 2011
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Description
HIV-specific Elispot responses were investigated in 57 antiretroviral therapy-naive children, of median age 9.9 years. CD8 T-cell responses were detected in 96% children; Nef was the immunodominant protein. Responses broadened over time, but there was no association between magnitude, breadth or specificity of response and viraemia. Gag-specific CD4 T-cell responses, detectable in 26% children, correlated inversely with viraemia (R = -0.43, P < 0.001), suggesting that preservation of this cell population may be an important goal of therapeutic/vaccine strategies. © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Authors & Co-Authors
Prendergast, Andrew J.
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Nuffield Department of Medicine
Clapson, Margaret
United Kingdom, London
Imperial College London
Tudor-Williams, Gareth
United Kingdom, London
Imperial College London
Riddell, Anna C.
United Kingdom, London
Barts and the London School of Medicine and Dentistry
Williams, Amanda J.
United Kingdom, Harrow
Northwick Park Hospital
Goulder, Philip Jeremy Renshaw
United Kingdom, Oxford
University of Oxford
Statistics
Citations: 18
Authors: 6
Affiliations: 6
Identifiers
Doi:
10.1097/QAD.0b013e3283478575
ISSN:
02699370
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study