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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Dietary intake of eicosapentaenoic and docosahexaenoic acids is linked to gray matter volume and cognitive function in elderly
Age, Volume 35, No. 4, Year 2013
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Description
In the present study, we tested whether elderly with a high dietary intake of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) would have higher cognitive test scores and greater brain volume than those with low dietary intake of these fatty acids. Data were obtained fromthe Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) cohort. The dietary intake of EPA and DHAwas determined by a 7- day food protocol in 252 cognitively healthy elderly (122 females) at the age of 70 years. At age 75, participants' global cognitive function was examined, and their brain volumes were measured by magnetic resonance imaging (MRI). Three different multivariate linear regression models were applied to test our hypothesis: model A (adjusted for gender and age), model B (additionally controlled for lifestyle factors, e.g., education), and model C (further controlled for cardiometabolic factors, e.g., systolic blood pressure). We found that the self-reported 7-day dietary intake of EPA and DHA at the age of 70 years was positively associated with global gray matter volume (P<0.05, except for model C) and increased global cognitive performance score (P<0.05). However, no significant associations were observed between the dietary intake of EPA and DHA and global white matter, total brain volume, and regional gray matter, respectively. Further, no effects were observed when examining cognitively impaired (n027) elderly as separate analyses. These cross-sectional findings suggest that dietary intake of EPA and DHA may be linked to improved cognitive health in late life but must be confirmed in patient studies. © 2012 The Author(s).
Authors & Co-Authors
Titova, Olga E.
Sweden, Uppsala
Uppsala Universitet
Sjögren, Per
Sweden, Uppsala
Uppsala Universitet
Brooks, Samantha Jane
Sweden, Uppsala
Uppsala Universitet
Kullberg, Joel
Sweden, Uppsala
Uppsala Universitet
Ax, Erika
Sweden, Uppsala
Uppsala Universitet
Kilander, Lena
Sweden, Uppsala
Uppsala Universitet
Risérus, Ulf
Sweden, Uppsala
Uppsala Universitet
Cederholm, Tommy E.
Sweden, Uppsala
Uppsala Universitet
Larsson, Elna Marie
Sweden, Uppsala
Uppsala Universitet
Johansson, Lars O.M.
Sweden, Uppsala
Uppsala Universitet
Åhlström, Håkan K.
Sweden, Uppsala
Uppsala Universitet
Lind, Lars L.
Sweden, Uppsala
Uppsala Universitet
Schiöth, Helgi Birgir
Sweden, Uppsala
Uppsala Universitet
Benedict, Christian
Sweden, Uppsala
Uppsala Universitet
Statistics
Citations: 79
Authors: 14
Affiliations: 1
Identifiers
Doi:
10.1007/s11357-012-9453-3
ISSN:
15744647
Research Areas
Food Security
Health System And Policy
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study
Participants Gender
Female