Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Protective effects of pituitary adenylate cyclase-activating polypeptide (PACAP) against apoptosis
Current Pharmaceutical Design, Volume 17, No. 3, Year 2011
Notification
URL copied to clipboard!
Description
Apoptosis is a regulated process leading to cell death, which is implicated both in normal development and in various pathologies including heart failure, stroke and neurodegenerative diseases. Caspase-3, a key enzyme of the apoptotic pathway, is considered as a major target for the treatment of abnormal cell death. Many factors that inhibit cell death have been identified, but the mechanisms involved are not always fully understood. Pituitary adenylate cylase-activating polypeptide (PACAP) has been shown to exert neuroprotective activities during development. PACAP also inhibits apoptosis in cardiomyopathy, decreases glutamate-induced retinal injury, reduces neuronal loss in case of stroke, and prevents ethanol neurotoxicity. Most of the antiapoptotic effects of PACAP are mediated through the PAC1 receptor. This receptor activates a transduction cascade of second messengers to stimulate Bcl-2 expression which inhibits cytochrome c release and blocks in turn caspase activation. PACAP also acts through the PI3K/Akt pathway and inhibits the expression of proapoptotic factors such as c-Jun or Bax. The remarkable effect of PACAP on the apoptotic cascade suggests that innovative PACAP derivatives could potentially be useful for treatment of post-traumatic lesions, chronic neurodegenerative diseases, cardiac ischemia and/or retinopathy. © 2011 Bentham Science Publishers Ltd.
Authors & Co-Authors
Seaborn, Tommy
Canada, Quebec
Chu de Québec-université Laval
France, Mont-saint-aignan
Dc2n - Différenciation et Communication Neuronale et Neuroendocrine
Masmoudi-Kouli, Olfa
Tunisia, Tunis
Université de Tunis el Manar, Faculté Des Sciences de Tunis
Fournier, Alain
Canada, Laval
Centre Armand-frappier Santé Biotechnologie
France, Mont-saint-aignan
Université de Rouen Normandie
Vaudry, Hubert
France, Mont-saint-aignan
Dc2n - Différenciation et Communication Neuronale et Neuroendocrine
France, Mont-saint-aignan
Université de Rouen Normandie
Vaudry, David
France, Mont-saint-aignan
Dc2n - Différenciation et Communication Neuronale et Neuroendocrine
France, Mont-saint-aignan
Université de Rouen Normandie
Statistics
Citations: 102
Authors: 5
Affiliations: 5
Identifiers
Doi:
10.2174/138161211795049679
ISSN:
13816128
e-ISSN:
18734286
Research Areas
Cancer
Health System And Policy
Noncommunicable Diseases
Violence And Injury