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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Dual role of IL-22 in allergic airway inflammation and its cross-talk with IL-17A
American Journal of Respiratory and Critical Care Medicine, Volume 183, No. 9, Year 2011
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Description
Rationale: IL-22 has both proinflammatory and antiinflammatory properties. Its role in allergic lung inflammation has not been explored. Objectives: To investigate the expression and roles of IL-22 in the onset and resolution of experimental allergic asthma and its crosstalk with IL-17A. Methods: IL-22 expression was assessed in patient samples and in the lung of mice immunized and challenged with ovalbumin. IL-22 functions in allergic airway inflammation were evaluated using mice deficient in IL-22 or anti-IL-22 neutralizing antibodies. Moreover, the effects of recombinant IL-22 and IL-17A neutralizing antibodies were investigated. Measurements and Main Results: Increased pulmonary IL-22 expression is found in the serum of patients with asthma and mice immunized and challenged with ovalbumin. Allergic lung inflammation is IL-22 dependent because eosinophil recruitment, Th2 cytokine including IL-13 and IL-33, chemokine production, airway hyperreactivity, and mucus production are drastically reduced in mice deficient in IL-22 or by IL-22 antibody neutralization during immunization of wild-type mice. By contrast, IL-22 neutralization during antigen challenge enhanced allergic lung inflammation with increased Th2 cytokines. Consistent with this, recombinant IL-22 given with allergen challengeprotectsmice from lunginflammation. Finally, IL-22 may regulate the expression and proinflammatory properties of IL-17A in allergic lung inflammation. Conclusions: IL-22 is required for the onset of allergic asthma, but functions as a negative regulator of established allergic inflammation. Our study reveals that IL-22 contributes to the proinflammatory properties of IL-17A in experimental allergic asthma. Copyright © 2011 American Thoracic Society.
Authors & Co-Authors
Besnard, Anne Gaëlle
France, Orleans
Université D'orléans
Sabat, Robert
Germany, Berlin
Charité – Universitätsmedizin Berlin
Dumoutier, Laure
Belgium, Brussels
Ludwig Institute for Cancer Research Brussels
Belgium, Brussels
De Duve Institute
Renauld, Jean-Christophe Christophe
Belgium, Brussels
Ludwig Institute for Cancer Research Brussels
Belgium, Brussels
De Duve Institute
Willart, Monique
Belgium, Ghent
Universitair Ziekenhuis Gent
Lambrecht, Bart Norbert
Belgium, Ghent
Universitair Ziekenhuis Gent
Teixeira, Mauro Martins
Brazil, Belo Horizonte
Universidade Federal de Minas Gerais
Charron, Sabine
France, Orleans
Université D'orléans
Fick, Lizette C.E.
South Africa, Cape Town
University of Cape Town
Erard, François
France, Orleans
Université D'orléans
Warszawska, Katarzyna
Germany, Berlin
Charité – Universitätsmedizin Berlin
Wolk, Kerstin
Germany, Berlin
Charité – Universitätsmedizin Berlin
Quesniaux, Valérie F.J.
France, Orleans
Université D'orléans
Ryffel, Bernhard
France, Orleans
Université D'orléans
Togbé, Dieudonnée
France, Orleans
Université D'orléans
France, Orleans
Artimmune Sas
Statistics
Citations: 206
Authors: 15
Affiliations: 8
Identifiers
Doi:
10.1164/rccm.201008-1383OC
ISSN:
1073449X
Research Areas
Health System And Policy
Maternal And Child Health