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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Plasmodium falciparum Na+/H+ exchanger 1 transporter is involved in reduced susceptibility to quinine
Antimicrobial Agents and Chemotherapy, Volume 53, No. 5, Year 2009
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Description
Polymorphisms in the Plasmodium falciparum crt (Pfcrt), Pfmdr1, and Pfmrp genes were not significantly associated with quinine (QN) 50% inhibitory concentrations (IC50s) in 23 strains of Plasmodium falciparum. An increased number of DNNND repeats in Pfnhe-1 microsatellite ms4760 was associated with an increased IC50 of QN (P = 0.0007). Strains with only one DNNND repeat were more susceptible to QN (mean IC50 of 154 nM). Strains with two DNNND repeats had intermediate susceptibility to QN (mean IC50 of 548 nM). Strains with three DNNND repeats had reduced susceptibility to QN (mean IC50 of 764 nM). Increased numbers of NHNDNHNNDDD repeats were associated with a decreased IC50 of QN (P = 0.0020). Strains with profile 7 for Pfnhe-1 ms4760 (ms4760-7) were significantly associated with reduced QN susceptibility (mean IC50 of 764 nM). The determination of DNNND and NHNDNHNNDDD repeats in Pfnhe-1 ms4760 could be a good marker of QN resistance and provide an attractive surveillance method to monitor temporal trends in P. falciparum susceptibility to QN. The validity of the markers should be further supported by analyzing more isolates. Copyright © 2009, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Henry, Maud
France, Marseille
Unité de Recherche Sur Les Maladies Infectieuses et Tropicales Emergentes
Briolant, Sébastien
France, Marseille
Unité de Recherche Sur Les Maladies Infectieuses et Tropicales Emergentes
Zettor, Agnès
France, Marseille
Unité de Recherche Sur Les Maladies Infectieuses et Tropicales Emergentes
Pelleau, Stéphane
France, Marseille
Imtssa Institut de Médecine Tropicale du Service de Santé Des Armées
Baragatti, Meili C.
France, Marseille
Unité de Recherche Sur Les Maladies Infectieuses et Tropicales Emergentes
Baret, Eric
France, Marseille
Unité de Recherche Sur Les Maladies Infectieuses et Tropicales Emergentes
Mosnier, Joël
France, Marseille
Unité de Recherche Sur Les Maladies Infectieuses et Tropicales Emergentes
Amalvict, Rémy
France, Marseille
Unité de Recherche Sur Les Maladies Infectieuses et Tropicales Emergentes
Fusaï, Thierry
France, Marseille
Unité de Recherche Sur Les Maladies Infectieuses et Tropicales Emergentes
Rogier, Christophe
France, Marseille
Unité de Recherche Sur Les Maladies Infectieuses et Tropicales Emergentes
Pradines, Bruno
France, Marseille
Unité de Recherche Sur Les Maladies Infectieuses et Tropicales Emergentes
France, Marseille
Centre National de Référence du Paludisme
France, Marseille
Imtssa Institut de Médecine Tropicale du Service de Santé Des Armées
Statistics
Citations: 61
Authors: 11
Affiliations: 3
Identifiers
Doi:
10.1128/AAC.01243-08
ISSN:
10986596