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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Risk factors for early childhood infection of human herpesvirus-8 in zambian children: The role of early childhood feeding practices
Cancer Epidemiology Biomarkers and Prevention, Volume 23, No. 2, Year 2014
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Description
Background: Human herpesvirus-8 (HHV-8) infection in early childhood is common throughout sub- Saharan Africa with prevalence increasing throughout childhood. Specific routes of transmission have not been clearly delineated, though HHV-8 is present in high concentrations in saliva. Methods: To understand the horizontal transmission of HHV-8 within households to children, we enrolled for cross-sectional analysis, 251 households including 254 children, age two and under, in Lusaka, Zambia. For all children, plasma was screened for HHV-8 and HIV type I (HIV-1) and health and behavioral questionnaires were completed. Multilevel logistic regression analysis was conducted to assess independent factors for HHV- 8 infection in children. Results: Risk factors for HHV-8 infection included increasing number of HHV-8-positive household members [OR 1/4 2.5; 95% confidence interval (CI), 1.9-3.3; P < 0.01] and having a primary caregiver who tested the temperature of food with their tongue before feeding the child (OR1/4 2.4; 95% CI, 1.93-3.30; P1/4 0.01). Breastfeeding was protective against infection with HHV-8 for children (OR 1/4 0.3; 95% CI, 0.16-0.72; P < 0.01). Conclusions: These results indicate that exposure to HHV-8 in the household increases risk for early childhood infection, with specific feeding behaviors likely playing a role in transmission. Impact: Interventions to protect children from infection should emphasize the possibility of infection through sharing of foods. © 2013 American Association for Cancer Research.
Authors & Co-Authors
Crabtree, Kay L.
United States, Lincoln
University of Nebraska–lincoln
Wojcicki, Janet Maia
United States, San Francisco
University of California, San Francisco
Minhas, Veenu
United States, Lincoln
University of Nebraska–lincoln
Smith, David R.
United States, Mississippi State
Msu College of Veterinary Medicine
Kankasa, Chipepo
Zambia, Lusaka
University of Zambia
Mitchell, Charles D.
United States, Miami
University of Miami Leonard M. Miller School of Medicine
Wood, Charles
United States, Lincoln
University of Nebraska–lincoln
Statistics
Citations: 27
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1158/1055-9965.EPI-13-0730
ISSN:
10559965
Research Areas
Cancer
Food Security
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Zambia