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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
neuroscience
Return of bradykinesia after subthalamic stimulation ceases: Relationship to electrode location
Experimental Neurology, Volume 231, No. 2, Year 2011
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Description
In 20 subjects we quantified the rate at which subthalamic nucleus deep brain stimulation effects on Parkinson's bradykinesia "washed-out" after stimulation ceased. We found that wash-out was a two-step process, consisting of an initial fast decrease in stimulation's therapeutic effect, followed by a further, slow decline. Moreover, the relative contribution of the fast and slow components differed between patients. Finally, we found that lateral stimulation caused more of the fast-decaying component, while medial stimulation caused more of the slow-decaying component. This implies the existence of at least two separate mechanisms by which subthalamic nucleus deep brain stimulation improves bradykinesia, associated with activation of spatially separate zones in the vicinity of the subthalamic nucleus. © 2011 Elsevier Inc.
Authors & Co-Authors
Cooper, Scott Evan
United States, Cleveland
Cleveland Clinic Foundation
Noecker, Angela Marie
United States, Cleveland
Cleveland Clinic Foundation
Abboud, Hesham
United States, Cleveland
Cleveland Clinic Foundation
Egypt, Alexandria
Faculty of Medicine
Vitek, Jerrold Lee
United States, Minneapolis
University of Minnesota Twin Cities
McIntyre, Cameron Charles
United States, Cleveland
Cleveland Clinic Foundation
Statistics
Citations: 25
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1016/j.expneurol.2011.06.010
ISSN:
00144886