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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Impact of APOE gene polymorphisms on the lipid profile in an Algerian population
Lipids in Health and Disease, Volume 12, No. 1, Article 155, Year 2013
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Description
Background: The importance of apolipoprotein E (APOE) in lipid and lipoprotein metabolism is well established. However, the impact of APOE polymorphisms has never been investigated in an Algerian population. This study assessed, for the fist time, the relationships between three APOE polymorphisms (epsilon, rs439401, rs4420638) and plasma lipid concentrations in a general population sample from Algeria. Methods. The association analysis was performed in the ISOR study, a representative sample of the population living in Oran (787 subjects aged between 30 and 64). Polymorphisms were considered both individually and as haplotypes. Results: In the ISOR sample, APOE 4 allele carriers had higher plasma triglyceride (p=0.0002), total cholesterol (p=0.009) and LDL-cholesterol (p=0.003) levels than 3 allele carriers. No significant associations were detected for the rs4420638 and rs439401 SNPs. Linkage disequilibrium and haplotype analyses confirmed the respectively deleterious and protective impacts of the 4 and 2 alleles on LDL-cholesterol levels and showed that the G allele of the rs4420638 polymorphism may exert a protective effect on LDL-cholesterol levels in subjects bearing the APOE epsilon 4 allele. Conclusion: Our results showed that (i) the APOE epsilon polymorphism has the expected impact on the plasma lipid profile and (ii) the rs4420638 G allele may counterbalance the deleterious effect of the 4 allele on LDL-cholesterol levels in an Algerian population. © 2013 Boulenouar et al.; licensee BioMed Central Ltd.
Authors & Co-Authors
Boulenouar, H.
Algeria, Oran
Université Des Sciences et de la Technologie D’oran Mohamed-boudiaf
Benchekor, Sounnia Mediene
Algeria, Oran
Université Des Sciences et de la Technologie D’oran Mohamed-boudiaf
Algeria, Oran
Université Oran 1
Meroufel, Djabaria Naïma
Algeria, Oran
Université Des Sciences et de la Technologie D’oran Mohamed-boudiaf
Hetraf, Sarah Aicha Lardjam
Algeria, Oran
Université Des Sciences et de la Technologie D’oran Mohamed-boudiaf
Ouhaïbi-Djellouli, Hadjira
Algeria, Oran
Université Des Sciences et de la Technologie D’oran Mohamed-boudiaf
Algeria, Oran
Université Oran 1
Hermant, Xavier
France, Lille
Université de Lille
Grenier-Boley, Benjamin
France, Lille
Université de Lille
Medjaoui, I.
Algeria, Oran
Clinique Specialisee en Orthopedie et Reeducation Des Victimes Des Accidents de Travail
Saïdi-Mehtar, Nadhira
Algeria, Oran
Université Des Sciences et de la Technologie D’oran Mohamed-boudiaf
Amouyel, Philippe
France, Lille
Université de Lille
Houti, Leïla
Algeria, Oran
Université Des Sciences et de la Technologie D’oran Mohamed-boudiaf
Algeria, Sidi Bel Abbes
Faculté de Médecine Taleb Mourad
Algeria, Oran
Université Oran 1
Meirhaeghe, Aline
France, Lille
Université de Lille
Goumidi, Louisa
France, Lille
Université de Lille
Statistics
Citations: 13
Authors: 13
Affiliations: 5
Identifiers
Doi:
10.1186/1476-511X-12-155
e-ISSN:
1476511X
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study
Study Locations
Algeria