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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Seasonal variation and high multiplicity of first Plasmodium falciparum infections in children from a holoendemic area in Ghana, West Africa
Tropical Medicine and International Health, Volume 11, No. 5, Year 2006
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Description
OBJECTIVE: To assess the prevalence and multiplicity of Plasmodium falciparum infections in Ghanaian infants. METHOD: In an epidemiological study in an area holoendemic for malaria in Ghana, the prevalence and multiplicity of P. falciparum infections (MOI) were assessed in 1069 three month-old infants by typing of the genes encoding the merozoite surface proteins 1 and 2 (msp-1, msp-2) over a recruitment period of one year. Alleles were amplified using allele family-specific polymerase chain reaction (PCR) assays and determined according to their length polymorphisms on a genetic analyzer. RESULTS: The occurrence of early infections was dependent on the season (month-stratified prevalence 6.4-29.0%). Diversity of msp-alleles was extensive and significantly higher in the dry than in the rainy season. CONCLUSIONS: The level of infection prevalence and the high multiplicity of infections (median 4, maximum 14 strains per isolate) in the first months of life indicate early contacts with parasites exhibiting a wide repertoire of antigens and, most likely, multiple infections per single mosquito bite. © 2006 Blackwell Publishing Ltd.
Authors & Co-Authors
Kobbe, Robin
Germany, Hamburg
Bernhard Nocht Institut Fur Tropenmedizin Hamburg
Neuhoff, Rieke
Germany, Hamburg
Bernhard Nocht Institut Fur Tropenmedizin Hamburg
Marks, Florian
Germany, Hamburg
Bernhard Nocht Institut Fur Tropenmedizin Hamburg
Adjei, Samuel
Germany, Hamburg
Bernhard Nocht Institut Fur Tropenmedizin Hamburg
Ghana, Accra
Ministry of Health Ghana
Langefeld, Iris
Germany, Hamburg
Bernhard Nocht Institut Fur Tropenmedizin Hamburg
von Reden, Claudia
Germany, Hamburg
Bernhard Nocht Institut Fur Tropenmedizin Hamburg
Adjei, Ohene
Ghana, Kumasi
Kumasi Centre for Collaborative Research in Tropical Medicine Kccr
Meyer, Christian G.
Germany, Hamburg
Bernhard Nocht Institut Fur Tropenmedizin Hamburg
May, Juergen ü.
Germany, Hamburg
Bernhard Nocht Institut Fur Tropenmedizin Hamburg
Statistics
Citations: 45
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1111/j.1365-3156.2006.01618.x
ISSN:
13602276
e-ISSN:
13653156
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Study Locations
Multi-countries
Ghana