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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
antigenic variation during Trypanosoma vivax infections of different host species
Parasitology, Volume 92, No. 1, Year 1986
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Description
The sequence of appearance of specific lytic activity against more than 20 variable antigen types (VATs) of Trypanosoma vivax in the serum of 27 animals belonging to 5 species has been examined. For each host species there was a characteristic course of infection, with differences in height and duration of parasitaemia and in pathogenicity. The sequence of antigenic variation was similar in all host species, with some VATs consistently eliciting response more rapidly than others. The predominant group, comprising VATs which apparently developed within the first 3 weeks, varied in size according to the total number of trypanosomes in the bloodstream within that period, suggesting there is a spectrum, rather than discrete groupings, in the hierarchy of VAT expression. There was very little evidence for differences in appearance of VATs between host species; the only clear example was one VAT which apparently did not develop in one host species. The sequence of antigenic variation in T. vivax seems to be determined by the parasite rather than the host species. © 1986, Cambridge University Press. All rights reserved.
Authors & Co-Authors
Barry, J. David
Kenya, Nairobi
International Laboratory for Research on Animal Diseases, Kenya
Statistics
Citations: 62
Authors: 1
Affiliations: 1
Identifiers
Doi:
10.1017/S0031182000063447
e-ISSN:
14698161