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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Brain charts for the human lifespan
Nature, Volume 604, No. 7906, Year 2022
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Description
Over the past few decades, neuroimaging has become a ubiquitous tool in basic research and clinical studies of the human brain. However, no reference standards currently exist to quantify individual differences in neuroimaging metrics over time, in contrast to growth charts for anthropometric traits such as height and weight1. Here we assemble an interactive open resource to benchmark brain morphology derived from any current or future sample of MRI data (http://www.brainchart.io/). With the goal of basing these reference charts on the largest and most inclusive dataset available, acknowledging limitations due to known biases of MRI studies relative to the diversity of the global population, we aggregated 123,984 MRI scans, across more than 100 primary studies, from 101,457 human participants between 115 days post-conception to 100 years of age. MRI metrics were quantified by centile scores, relative to non-linear trajectories2 of brain structural changes, and rates of change, over the lifespan. Brain charts identified previously unreported neurodevelopmental milestones3, showed high stability of individuals across longitudinal assessments, and demonstrated robustness to technical and methodological differences between primary studies. Centile scores showed increased heritability compared with non-centiled MRI phenotypes, and provided a standardized measure of atypical brain structure that revealed patterns of neuroanatomical variation across neurological and psychiatric disorders. In summary, brain charts are an essential step towards robust quantification of individual variation benchmarked to normative trajectories in multiple, commonly used neuroimaging phenotypes. © 2022, The Author(s).
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Authors & Co-Authors
Bethlehem, Richard A.I.
United Kingdom, Cambridge
University of Cambridge
Seidlitz, Jakob
United States, Philadelphia
University of Pennsylvania
United States, Philadelphia
The Children's Hospital of Philadelphia
United States, Philadelphia
Penn Medicine
White, Simon R.
United Kingdom, Cambridge
University of Cambridge
Vogel, Jacob William
United States, Philadelphia
University of Pennsylvania
Anderson, Kevin M.
United States, New Haven
Yale University
Adamson, Chris L.
Australia, Melbourne
Murdoch Children's Research Institute
Australia, Clayton
Monash University
Adler, Sophie
United Kingdom, London
University College London
Alexopoulos, George
United States, New York
Weill Cornell Medicine
Anagnostou, Evdokia A.
Canada, Toronto
University of Toronto
Canada, Toronto
Holland Bloorview Kids Rehabilitation Hospital
Areces-González, Ariosky
China, Chengdu
University of Electronic Science and Technology of China
Cuba
Universidad de Pinar Del Rio
Astle, Duncan Edward
United Kingdom, Cambridge
University of Cambridge
Auyeung, Bonnie
United Kingdom, Cambridge
University of Cambridge
United Kingdom, Edinburgh
The University of Edinburgh
Bae, Jong-bin
South Korea, Seongnam
Seoul National University Bundang Hospital
Ball, Gareth
Australia, Melbourne
Murdoch Children's Research Institute
Australia, Melbourne
University of Melbourne
Baron-Cohen, Simon
United Kingdom, Cambridge
University of Cambridge
United Kingdom, Cambridge
Cambridgeshire and Peterborough Nhs Foundation Trust
Beare, Richard J.
Australia, Melbourne
Murdoch Children's Research Institute
Australia, Clayton
Monash University
Bedford, Saashi A.
United Kingdom, Cambridge
University of Cambridge
Benegal, Vivek
India, Bengaluru
National Institute of Mental Health and Neuro Sciences
Beyer, Frauke
Germany, Leipzig
Max Planck Institute for Human Cognitive and Brain Sciences
Blangero, John
United States, Brownsville
The University of Texas Rio Grande Valley
Blesa-Cábez, Manuel
United Kingdom, Edinburgh
The University of Edinburgh
Borzage, Matthew T.
United States, Los Angeles
University of Southern California
Bosch-Bayard, Jorge F.
Canada, Montreal
Université Mcgill
Bourke, Niall J.
United Kingdom, London
Imperial College London
United Kingdom, London
Uk Dementia Research Institute
Calhoun, Vince D.
United States, Atlanta
Georgia Institute of Technology
Chakravarty, M. Mallar Mallar
Canada, Montreal
Université Mcgill
Canada, Montreal
Institut Universitaire en Santé Mentale Douglas
Chen, Christina
United States, Philadelphia
University of Pennsylvania
Chertavian, Casey
United States, Philadelphia
Penn Medicine
Chetélat, Gaël
France, Caen
Normandie Université
Chong, Yap Seng
Singapore, Singapore City
Agency for Science, Technology and Research, Singapore
Singapore, Singapore City
National University of Singapore
Cole, James H.
United Kingdom, London
University College London
Corvin, Aiden P.
Ireland, Dublin
Trinity College Dublin
Costantino, Manuela
Canada, Montreal
Institut Universitaire en Santé Mentale Douglas
Canada, Montreal
Université Mcgill
Courchesne, Eric H.
United States, La Jolla
University of California, San Diego
Crivello, Fabrice
France, Gif-sur-yvette
Commissariat a L'energie Atomique et Aux Energies Alternatives
Cropley, Vanessa Louise
Australia, Melbourne
University of Melbourne
Crosbie, Jennifer
Canada, Toronto
Hospital for Sick Children University of Toronto
Crossley, Nicolas A.
Chile, Santiago
Pontificia Universidad Católica de Chile
United Kingdom, London
King's College London
Chile, Santiago
Universidad Andrés Bello
Delarue, Marion
France, Caen
Normandie Université
Delorme, Richard
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
France, Paris
Institut Pasteur, Paris
Desrivières, Sylvane
United Kingdom, London
King's College London
Devenyi, Gabriel Allan
Canada, Montreal
Institut Universitaire en Santé Mentale Douglas
Canada, Montreal
Université Mcgill
Donald, Kirsten A.
South Africa, Cape Town
Red Cross War Memorial Children's Hospital
South Africa, Cape Town
University of Cape Town
Donohoe, Gary J.
Ireland, Galway
University of Galway
Dunlop, Katharine A.M.
United States, New York
Weill Cornell Medicine
Edwards, Anthony David
United Kingdom, London
King's College London
United Kingdom, London
Evelina London Children's Healthcare
Elison, Jed T.
United States, Minneapolis
University of Minnesota Twin Cities
Ellis, Cameron T.
United States, New Haven
Yale University
United States, New Haven
Haskins Laboratories new Haven
Elman, Jeremy A.
United States, La Jolla
University of California, San Diego
Eyler, Lisa Todd
United States, San Diego
Va San Diego Healthcare System
United States, La Jolla
University of California, San Diego
Fair, Damien A.
United States, Minneapolis
University of Minnesota Twin Cities
Feczko, Eric J.
United States, Minneapolis
University of Minnesota Twin Cities
Fletcher, Paul Charles
United Kingdom, London
Wellcome Trust
United Kingdom, Cambridge
Cambridgeshire and Peterborough Nhs Foundation Trust
Franz, Carol E.
United States, La Jolla
University of California, San Diego
Galán-García, Lídice G.
Cuba, Havana
Centro de Neurociencias de Cuba
Gholipour, Ali
United States, Boston
Boston Children's Hospital
Giedd, Jay Norman
United States, La Jolla
University of California, San Diego
Gilmore, John H.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Glahn, David C.
United States, Boston
Harvard Medical School
Goodyer, Ian Michael
United Kingdom, Cambridge
University of Cambridge
Groenewold, Nynke A.
South Africa, Cape Town
University of Cape Town
South Africa, Tygerberg
South African Medical Research Council
Gunning-Dixon, Faith M.
United States, New York
Weill Cornell Medicine
Gur, Raquel E.
United States, Philadelphia
University of Pennsylvania
United States, Philadelphia
Penn Medicine
Gur, Ruben C.
United States, Philadelphia
University of Pennsylvania
United States, Philadelphia
Penn Medicine
Hammill, Christopher F.
Canada, Toronto
Hospital for Sick Children University of Toronto
Canada, Toronto
Mouse Imaging Centre
Hansson, Oskar
Sweden, Lund
Lunds Universitet
Sweden, Lund
Skånes Universitetssjukhus
Hedden, Trey
United States, New York
Icahn School of Medicine at Mount Sinai
United States, Boston
Massachusetts General Hospital
Heinz, Andreas
Germany, Berlin
Freie Universität Berlin
Henson, Richard N.A.
United Kingdom, Cambridge
University of Cambridge
Heuer, Katja
Germany, Leipzig
Max Planck Institute for Human Cognitive and Brain Sciences
France, Paris
Université Paris Cité
Hoare, Jacqueline
South Africa, Cape Town
University of Cape Town
Holla, Bharath
India, Bengaluru
National Institute of Mental Health and Neuro Sciences
Holmes, Avram J.
United States, New Haven
Yale School of Medicine
Holt, Rosemary J.
United Kingdom, Cambridge
University of Cambridge
Huang, Hao
United States, Philadelphia
The Children's Hospital of Philadelphia
United States, Philadelphia
University of Pennsylvania
Im, Kiho
United States, Boston
Harvard Medical School
Ipser, Jonathan C.
South Africa, Cape Town
University of Cape Town
Jack, Clifford R.
United States, Rochester
Mayo Clinic
Jackowski, Andrea Parolin
Brazil, Sao Paulo
Universidade Federal de São Paulo
China, Beijing
Institute of Developmental Biology
Jia, Tianye
China, Shanghai
Fudan University
China, Beijing
Ministry of Education of the People's Republic of China
United Kingdom, London
King's College London
Johnson, Keith A.
United States, Boston
Harvard Medical School
United States, Boston
Massachusetts General Hospital
United States, Boston
Brigham and Women's Hospital
Jones, Peter B.
United Kingdom, Cambridge
University of Cambridge
United Kingdom, Cambridge
Cambridgeshire and Peterborough Nhs Foundation Trust
Jones, David Thomas
United States, Rochester
Mayo Clinic
Kahn, René Sylvain
United States, New York
Icahn School of Medicine at Mount Sinai
Karlsson, Hasse K.
Finland, Turku
Turun Yliopisto
Karlsson, Linnea
Finland, Turku
Turun Yliopisto
Kawashima, Ryuta
Japan, Sendai
Tohoku University
Kelley, Elizabeth A.
Canada, Kingston
Queen’s University
Kern, Silke
Sweden, Gothenburg
Göteborgs Universitet
Sweden, Gothenburg
Sahlgrenska Universitetssjukhuset
Kim, Kiwoong
South Korea, Seoul
College of Natural Sciences
South Korea, Seongnam
Seoul National University Bundang Hospital
South Korea, Seoul
Seoul National University College of Medicine
South Korea, Seoul
Seoul National University
Kitzbichler, Manfred G.
United Kingdom, Cambridge
University of Cambridge
Kremen, William S.
United States, La Jolla
University of California, San Diego
Lalonde, François M.
United States, Bethesda
Instituto Nacional de la Salud Mental
Landeau, Brigitte
France, Caen
Normandie Université
Lerch, Jason P.
Canada, Toronto
University of Toronto
United Kingdom, Oxford
University of Oxford
Liao, Wei
China, Chengdu
University of Electronic Science and Technology of China
Lombardo, Michael Vincent
United Kingdom, Cambridge
University of Cambridge
Italy, Genoa
Istituto Italiano Di Tecnologia
Mathias, Samuel R.
United States, Boston
Harvard Medical School
Mazoyer, Bernard M.
France, Gif-sur-yvette
Commissariat a L'energie Atomique et Aux Energies Alternatives
McGuire, Philip K.
United Kingdom, London
King's College London
Meaney, Michael J.
Singapore, Singapore City
A-star, Singapore Institute for Clinical Sciences
Mechelli, Andrea
France, Talence
Centre Hospitalier Universitaire de Bordeaux
Mišić, Bratislav
Canada, Montreal
Université Mcgill
Mothersill, David O.
Ireland, Dublin
National College of Ireland
Ireland, Galway
University of Galway
Ireland, Dublin
Trinity College Dublin
Palaniyappan, Lena
Canada, London
Western University
Pan, Pedro Mario
Unknown Affiliation
Pantelis, Christos S.
Australia, Melbourne
Melbourne Health
Australia, Melbourne
University of Melbourne
Australia, Melbourne
The Florey
Paus, Tomáš
Canada, Montreal
Chu Sainte-justine - le Centre Hospitalier Universitaire Mère-enfant
Canada, Toronto
University of Toronto
Pausová, Zdenka
Canada, Toronto
Hospital for Sick Children University of Toronto
Canada, Toronto
University of Toronto
Qiu, Jiang
China, Chongqing
Southwest University
Qiu, Anqi
Singapore, Singapore City
National University of Singapore
Rodrigue, Amanda L.
United States, Boston
Harvard Medical School
Rollins, Caitlin K.
United States, Boston
Harvard Medical School
United States, Boston
Boston Children's Hospital
Romero-Garcia, Rafael
United Kingdom, Cambridge
University of Cambridge
Spain, Madrid
Consejo Superior de Investigaciones Científicas
Ronan, Lisa
United Kingdom, Cambridge
University of Cambridge
Rowitch, David H.
United Kingdom, Cambridge
Wellcome - Mrc Cambridge Stem Cell Institute
Salum, Giovanni Abrahão
Brazil, Porto Alegre
Universidade Federal do Rio Grande do Sul
Satterthwaite, Theodore Daniel
United States, Philadelphia
University of Pennsylvania
Schumann, Gunter
China, Shanghai
Fudan University
Germany, Berlin
Charité – Universitätsmedizin Berlin
Shinohara, Russell Takeshi
United States, Philadelphia
University of Pennsylvania
United States, Philadelphia
University of Pennsylvania Perelman School of Medicine
Skoog, Ingmar
Sweden, Gothenburg
Göteborgs Universitet
Sweden, Gothenburg
Sahlgrenska Universitetssjukhuset
Smyser, Christopher D.
United States, St. Louis
Washington University School of Medicine in St. Louis
Stein, Dan J.
South Africa, Cape Town
Sa Mrc Unit on Risk and Resilience in Mental Disorders
Stolicyn, Aleks
United Kingdom, Edinburgh
The University of Edinburgh
Suckling, John
United Kingdom, Cambridge
University of Cambridge
United Kingdom, Cambridge
Cambridgeshire and Peterborough Nhs Foundation Trust
Toro, Roberto
France, Paris
Université Paris Cité
France, Paris
Institut Pasteur, Paris
Traut, Nicolas
France, Paris
Institut Pasteur, Paris
France, Paris
Université Paris Cité
Tsvetanov, Kamen A.
United Kingdom, Cambridge
University of Cambridge
Tzourio, C.
France, Talence
Centre Hospitalier Universitaire de Bordeaux
Valdés-Sosa, Pedro A.
China, Chengdu
University of Electronic Science and Technology of China
Canada, Montreal
Université Mcgill
Valk, Sofie Louise
Germany, Julich
Forschungszentrum Jülich Gmbh
Germany, Leipzig
Max Planck Institute for Human Cognitive and Brain Sciences
van Amelsvoort, Thérèse A.M.J.
Netherlands, Maastricht
Universiteit Maastricht
Villringer, Arno M.d.
Germany, Leipzig
Max Planck Institute for Human Cognitive and Brain Sciences
Germany, Leipzig
Universität Leipzig
Warrier, Varun
United Kingdom, Cambridge
University of Cambridge
Westman, Eric
Sweden, Stockholm
Karolinska Institutet
Whalley, Heather Clare
United Kingdom, Edinburgh
The University of Edinburgh
Witte, A.Veronica
Germany, Leipzig
Max Planck Institute for Human Cognitive and Brain Sciences
Germany, Leipzig
Universität Leipzig
Zalesky, Andrew
Australia, Melbourne
University of Melbourne
Zar, Heather J.
South Africa, Tygerberg
South African Medical Research Council
Australia, Melbourne
University of Melbourne
Zugman, André
United States, Bethesda
National Institutes of Health Nih
Brazil, Sao Paulo
Universidade Federal de São Paulo
Alexander-Bloch, Aaron F.
United States, Philadelphia
University of Pennsylvania
United States, Philadelphia
The Children's Hospital of Philadelphia
United States, Philadelphia
Penn Medicine
Statistics
Citations: 518
Authors: 141
Affiliations: 119
Identifiers
Doi:
10.1038/s41586-022-04554-y
ISSN:
00280836
Research Areas
Mental Health
Study Design
Cross Sectional Study
Cohort Study