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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Pan-African polyspecific antivenom produced by caprylic acid purification of horse IgG: An alternative to the antivenom crisis in Africa
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 99, No. 6, Year 2005
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Description
A polyspecific Pan-African antivenom has been produced from the plasma of horses immunized with a mixture of the venoms of Echis ocellatus, Bitis arietans and Naja nigricollis, the three most medically important snakes in sub-Saharan Africa. The antivenom is a whole IgG preparation, obtained by caprylic acid precipitation of non-IgG plasma proteins. The antivenom effectively neutralizes the most important toxic activities of the three venoms used in the immunization in standard assays involving preincubation of venom and antivenom before testing. This antivenom compares favourably with other antivenoms designed for use in Africa with respect to neutralization of the toxins present in the venom of E. ocellatus. Caprylic acid fractionation of horse hyperimmune plasma is a simple, convenient and cheap protocol for the manufacture of high quality whole IgG antivenoms. It constitutes a potentially valuable technology for the alleviation of the critical shortage of antivenom in Africa. © 2004 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Gutierrez, José Maria
Costa Rica, San Jose
Universidad de Costa Rica
Rojas, E.
Costa Rica, San Jose
Universidad de Costa Rica
Quesada, L.
Costa Rica, San Jose
Universidad de Costa Rica
León, Guillermo
Costa Rica, San Jose
Universidad de Costa Rica
Núñez, J.
Costa Rica, San Jose
Universidad de Costa Rica
Laing, Gavin David
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Sasa, M.
Costa Rica, San Jose
Universidad de Costa Rica
Renjifo, Juan Manuel
Colombia, Bogota
Instituto de Investigación de Recursos Biológicos Alexander Von Humboldt, Bogota
Nasidi, Abdulsalami Salam
Nigeria, Abuja
Federal Ministry of Health
Warrell, David A.
United Kingdom, Oxford
Nuffield Department of Medicine
Theakston, Robert David Geoffrey
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Rojas, G.
Costa Rica, San Jose
Universidad de Costa Rica
Statistics
Citations: 102
Authors: 12
Affiliations: 5
Identifiers
Doi:
10.1016/j.trstmh.2004.09.014
ISSN:
00359203
Research Areas
Environmental
Health System And Policy
Maternal And Child Health