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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The epidemiology of rotavirus diarrhea in Countries in the eastern mediterranean region
Journal of Infectious Diseases, Volume 202, No. SUPPL. 1, Year 2010
Notification
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Description
Objective. Rotavirus is the leading cause of severe diarrhea among children worldwide, killing ~600,000 children annually, including 64,800 in the Eastern Mediterranean Region. Safe, effective rotavirus vaccines will be available soon, and accurate disease burden data will be needed to assess the burden of rotavirus and the value of new vaccines and monitor vaccine program impact. Methods. To identify epidemiologic studies in which rotavirus diagnostics were applied to children with acute gastroenteritis, we performed a systematic literature review. We selected studies that met 4 criteria and extracted rotavirus data on prevalence estimates, strain identification, age distribution of patients, and seasonal trends. Results. Of the 63 published studies with some rotavirus detection data, 29 met inclusion criteria. Among patients with diarrhea, rotavirus was detected in 40% of inpatients and 23% of outpatients. By 3 years of age, 75% of children experienced a documented rotavirus infection. Circulation of rotavirus occurred year-round, and no clear relationship between the timing of the rotavirus peak with either season or latitude was observed. Comparison of country-specific rotavirus detection rates indicated that the proportion of hospitalizations for rotavirus infection increased with income. Conclusion. This systematic review of studies of rotavirus diarrhea among children in the countries of the Eastern Mediterranean Region documents that rotavirus is one of the most significant causes of childhood diarrhea in the region. The findings of this review will be used to establish sentinel hospital surveillance in these countries,estimate disease burden, and characterize its epidemiology using common protocols and diagnostics. © 2010 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Malek, Mark A.
United States, Atlanta
Centers for Disease Control and Prevention
United States, Atlanta
Viral and Rickettsial Zoonoses Br.
Teleb, Nadia A.
Switzerland, Geneva
Organisation Mondiale de la Santé
Abu-Elyazeed, Remon R.
United States, Philadelphia
Glaxosmithkline, Usa
Riddle, Mark S.
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
Sherif, May
United States, Atlanta
Centers for Disease Control and Prevention
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
Steele, Andrew Duncan
Switzerland, Geneva
Organisation Mondiale de la Santé
Glass, Roger I.M.
United States, Atlanta
Centers for Disease Control and Prevention
Bresee, Joseph S.
United States, Atlanta
Centers for Disease Control and Prevention
Statistics
Citations: 64
Authors: 8
Affiliations: 5
Identifiers
Doi:
10.1086/653579
ISSN:
00221899
Research Areas
Health System And Policy
Maternal And Child Health
Study Design
Cross Sectional Study
Study Approach
Systematic review