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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Vitamin D supplementation as an adjuvant therapy for patients with T2DM: An 18-month prospective interventional study
Cardiovascular Diabetology, Volume 11, Article 85, Year 2012
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Description
Background: Vitamin D deficiency has been associated with impaired human insulin action, suggesting a role in the pathogenesis of diabetes mellitus type 2 (T2DM). In this prospective interventional study we investigated the effects of vitamin D3 supplementation on the metabolic profiles of Saudi T2DM subjects pre- and post-vitamin D supplementation over an 18-month period.Methods: T2DM Saudi subjects (men, N = 34: Age: 56.6 ± 8.7 yr, BMI, 29.1 ± 3.3 kg/m2; women, N = 58: Age: 51.2 ± 10.6 yr, BMI 34.3 ± 4.9 kg/m2;) were recruited and given 2000 IU vitamin D3 daily for 18 months. Anthropometrics and fasting blood were collected (0, 6, 12, 18 months) to monitor serum 25-hydroxyvitamin D using specific ELISA, and to determine metabolic profiles by standard methods.Results: In all subjects there was a significant increase in mean 25-hydroxyvitamin D levels from baseline (32.2 ± 1.5 nmol/L) to 18 months (54.7 ± 1.5 nmol/L; p < 0.001), as well as serum calcium (baseline = 2.3 ± 0.23 mmol/L vs. 18 months = 2.6 ± 0.1 mmol/L; p = 0.003). A significant decrease in LDL- (baseline = 4.4 ± 0.8 mmol/L vs. 18 months = 3.6 ± 0.8 mmol/L, p < 0.001] and total cholesterol (baseline = 5.4 ± 0.2 mmol/L vs. 18 months = 4.9 ± 0.3 mmol/L, p < 0.001) were noted, as well as a significant improvement in HOMA-β function (p = 0.002). Majority of the improvements elicited were more prominent in women than men.Conclusion: In the Saudi T2DM population receiving oral Vitamin D3 supplementation (2000 IU/day), circulating 25-hydroxyvitamin D levels remained below normal 18 months after the onset of treatment. Yet, this " suboptimal" supplementation significantly improved lipid profile with a favorable change in HDL/LDL ratio, and HOMA-β function, which were more pronounced in T2DM females. © 2012 Al-Daghri et al.; licensee BioMed Central Ltd.
Authors & Co-Authors
Al-Daghri, N. Mohammad
Saudi Arabia, Riyadh
College of Sciences
Saudi Arabia, Riyadh
King Saud University
Alkharfy, Khalid Mohammad
Saudi Arabia, Riyadh
College of Sciences
Saudi Arabia, Riyadh
King Saud University
Saudi Arabia, Riyadh
College of Pharmacy
Al-Othman, Abdulaziz M.
Saudi Arabia, Riyadh
College of Applied Medical Sciences
El-Kholie, Emad M.
Saudi Arabia, Riyadh
College of Sciences
Moharram, Osama A.
Saudi Arabia, Jeddah
King Abdulaziz University
Alokail, Majed Saleh
Saudi Arabia, Riyadh
College of Sciences
Saudi Arabia, Riyadh
King Saud University
al-Saleh, Yousef M.
Saudi Arabia, Riyadh
King Saud University
Sabico, Shaun
Saudi Arabia, Riyadh
College of Sciences
Saudi Arabia, Riyadh
King Saud University
Kumar, Sudhesh
United Kingdom, Coventry
Clinical Sciences Research Institute
Chrousos, George Panagiotis
Saudi Arabia, Riyadh
College of Sciences
Greece, Athens
School of Medicine
Statistics
Citations: 82
Authors: 10
Affiliations: 7
Identifiers
Doi:
10.1186/1475-2840-11-85
Research Areas
Health System And Policy
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study
Participants Gender
Male
Female