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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
dentistry
Bioactive nanofibrous scaffolds for regenerative endodontics
Journal of Dental Research, Volume 92, No. 11, Year 2013
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Description
Here we report the synthesis, materials characterization, antimicrobial capacity, and cytocompatibility of novel antibiotic-containing scaffolds. Metronidazole (MET) or Ciprofloxacin/(CIP) was mixed with a polydioxanone (PDS)polymer solution at 5 and 25 wt% and processed into fibers. PDS fibers served as a control. Scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), tensile testing, and high-performance liquid chromatography (HPLC) were used to assess fiber morphology, chemical structure, mechanical properties, and drug release, respectively. Antimicrobial properties were evaluated against those of Porphyromonas gingivalis/Pg and Enterococcus faecalis/Ef. Cytotoxicity was assessed in human dental pulp stem cells (hDPSCs). Statistics were performed, and significance was set at the 5% level. SEM imaging revealed a submicron fiber diameter. FTIR confirmed antibiotic incorporation. The tensile values of hydrated 25 wt% CIP scaffold were significantly lower than those of all other groups. Analysis of HPLC data confirmed gradual, sustained drug release from the scaffolds over 48 hrs. CIP-containing scaffolds significantly (p <.00001) inhibited biofilm growth of both bacteria. Conversely, MET-containing scaffolds inhibited only Pg growth. Agar diffusion confirmed the antimicrobial properties against specific bacteria for the antibiotic-containing scaffolds. Only the 25 wt% CIP-containing scaffolds were cytotoxic. Collectively, this study suggests that polymer-based antibiotic-containing electrospun scaffolds could function as a biologically safe antimicrobial drug delivery system for regenerative endodontics. © International & American Associations for Dental Research.
Authors & Co-Authors
Bottino, Marco C.
United States, Indianapolis
Indiana University School of Dentistry
Kamocki, K.
United States, Indianapolis
Indiana University School of Dentistry
Yassen, Ghaeth
United States, Indianapolis
Indiana University School of Dentistry
Iraq, Mosul
University of Mosul
Platt, Jeffrey A.
United States, Indianapolis
Indiana University School of Dentistry
Vail, M. M.
United States, Indianapolis
Indiana University School of Dentistry
Ehrlich, Y.
United States, Indianapolis
Indiana University School of Dentistry
Spolnik, Kenneth J.
United States, Indianapolis
Indiana University School of Dentistry
Gregory, Richard Lee
United States, Indianapolis
Indiana University School of Dentistry
Statistics
Citations: 148
Authors: 8
Affiliations: 2
Identifiers
Doi:
10.1177/0022034513505770
ISSN:
00220345
e-ISSN:
15440591
Research Areas
Cancer
Health System And Policy