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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Immunological and histological effects of exposure to imidacloprid insecticide in male albino rats
African Journal of Pharmacy and Pharmacology, Volume 5, No. 18, Year 2011
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Description
Imidacloprid (IC) is a relatively new systemic insecticide related to the tobacco toxin nicotine. The effects of repeated oral administration of IC over 4 weeks on immune response, oxidative stress and hepatotoxicity were assessed. Forty-eight adult male albino rats were divided into two groups of twenty-four animals each. The control group was orally administered distilled water, while the IC-treated group was orally administered 1/100 LD50 (0.21 mg/ kg body weight) of IC insecticide daily. We found a significant increase in the total leukocyte count, total immunoglobulins (Igs) especially IgG. In contrast, significant decreases in phagocytic activity, chemokinesis and chemotaxis were observed in the IC treated group compared to the control group. Histopathologically, the spleen tissues of the IC-treated rats displayed low numbers of lymphocytes, some of which appeared to be pyknotic. However, both fibroblasts and bundles, such as trabeculae, occurred in greater numbers. Similarly, thymus tissues in the IC-treated group showed lymphocytic depletion with pyknotic nuclei. Additionally, significant increases in the serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), alkaline phosphatase (ALP) and malondialdehyde (MDA) were observed in the IC-treated group. Accordingly, in the IC-treated group, heavily congested central vein and blood sinusoids were observed in the liver tissues; pyknotic nuclei were found throughout the hepatic tissue, and leukocyte infiltration was observed. In summary, these results suggest that exposure to 1/100 LD50 of IC induces immunotoxicity, oxidative stress, lipid peroxidation and hepatotoxicity. © 2011 Academic Journals.
Authors & Co-Authors
Mohany, Mohamed
Saudi Arabia, Riyadh
College of Sciences
Egypt, Minya
Faculty of Science
Badr, Gamal
Saudi Arabia, Riyadh
College of Sciences
Egypt, Asyut
Faculty of Science
Refaat, Inas Hussein
Egypt, Minya
Faculty of Science
El-Feki, Moustafa
Egypt, Minya
Faculty of Science
Statistics
Citations: 60
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.5897/AJPP11.625
e-ISSN:
19960816
Research Areas
Environmental
Health System And Policy
Substance Abuse
Study Design
Randomised Control Trial
Participants Gender
Male