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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Anti-Saccharomyces cerevisiae antibodies in patients with systemic lupus erythematosus
Rheumatology International, Volume 33, No. 3, Year 2013
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Description
Anti-Saccharomyces cerevisiae antibodies (ASCA) had been known to be specific for Crohn's disease but it has been found in many other autoimmune diseases like systemic lupus erythematosus (SLE). Furthermore, cross-reactive epitopes on β2-glycoprotein I (β2GPI) and Saccharomyces cerevisiae were found in SLE patients. The aims of this study were to evaluate the frequency of ASCA in patients with SLE and to compare it with that of anti-β2GPI antibodies (aβ2GPI). Sera of 116 patients with SLE were analyzed in this retrospective study. All patients fulfilled at least 4 criteria of the 1997 American College of Rheumatology updated criteria for the classification of SLE. Sera of 160 blood donors were included as normal controls. ASCA IgA and IgG and aβ2GPI antibodies were determined by enzyme-linked immunosorbent assays. The frequency of ASCA (IgG and/or IgA) was significantly higher in SLE patients than in control group (31.9 vs. 3.7 %, p < 10-6). ASCA IgG and ASCA IgA were more frequent in SLE patients than in control group (29.3 vs. 3.1 %, p < 10-6 and 12.1 vs. 0.6 %, p = 10-4, respectively). The mean level of ASCA IgG was higher than that of ASCA IgA (9.5 vs. 6.4 U/ml) but the difference was not statistically significant. The frequencies of aβ2GPI (IgG and/or IgA) and aβ2GPI IgA were significantly higher than those of ASCA (IgG and/or IgA) and ASCA IgA (54.3 vs. 31.9 %, p = 5 × 10-4 and 50.9 vs. 12.1 %, p < 10-6, respectively). Increased ASCA IgG was observed in patients with SLE, suggesting a role of environmental stimuli in its pathogenesis. © 2012 Springer-Verlag.
Authors & Co-Authors
Mankaï, Amani
Tunisia, Monastir
Research Unit 03ur/07-02
Sakly, Wahiba
Tunisia, Monastir
Research Unit 03ur/07-02
Thabet, Yosra
Tunisia, Monastir
Research Unit 03ur/07-02
Achour, Achouak
Tunisia, Monastir
Research Unit 03ur/07-02
Manoubi, Wiem
Tunisia, Monastir
Research Unit 03ur/07-02
Ghédira, Ibtissem
Tunisia, Monastir
Research Unit 03ur/07-02
Tunisia, Sousse
Hopital Farhat Hached Sousse
Statistics
Citations: 6
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1007/s00296-012-2431-3
ISSN:
01728172
e-ISSN:
1437160X
Study Design
Randomised Control Trial
Cohort Study