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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
An unusual distribution of the kdr gene among populations of Anopheles gambiae on the island of Bioko, Equatorial Guinea
Insect Molecular Biology, Volume 14, No. 6, Year 2005
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Description
In West Africa, Anopheles gambiae exists in discrete subpopulations known as the M and S molecular forms. Although these forms occur in sympatry, pyrethroid knock-down resistance (kdr) is strongly associated with the S molecular form. On the island of Bioko, Equatorial Guinea we found high frequencies of the kdr mutation in M form individuals (55.8%) and a complete absence of kdr in the S form. We also report the absence of the kdr allele in M and S specimens from the harbour town of Tiko in Cameroon, representing the nearest continental population to Bioko. The kdr allele had previously been reported as absent in populations of An. gambiae on Bioko. Contrary to earlier reports, sequencing of intron-1 of this sodium channel gene revealed no fixed differences between M form resistant and susceptible individuals. The mutation may have recently arisen independently in the M form on Bioko due to recent and intensive pyrethroid application. © 2005 The Royal Entomological Society.
Authors & Co-Authors
Reimer, Lisa J.
United States, Davis
University of California, Davis
Tripét, Frédéric R.
United States, Davis
University of California, Davis
Slotman, Michel Andre
United States, Davis
University of California, Davis
Spielman, Andrew
United States, Cambridge
Harvard University
Fondjo, Etienne
Cameroon, Yaounde
Ministry of Health
Lanzaro, Gregory C.
United States, Davis
University of California, Davis
Statistics
Citations: 80
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1111/j.1365-2583.2005.00599.x
ISSN:
09621075
e-ISSN:
13652583
Research Areas
Cancer
Genetics And Genomics
Study Design
Cross Sectional Study
Study Locations
Multi-countries
Cameroon
Equatorial Guinea
Guinea