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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Bioinformatic analysis of the hepadnavirus e-antigen and its precursor identifies remarkable sequence conservation in all orthohepadnaviruses
Journal of Medical Virology, Volume 82, No. 1, Year 2010
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Description
The hepatitis B e-antigen (HBeAg) is a nonparticulate secretory protein expressed by all viruses within the family Hepadnaviridae. It is not essential for viral assembly or replication but is important for establishment of persistent infection in vivo. Although the exact mechanism(s) by which the HBeAg manifests chronicity are unclear, the HBeAg elicits both humoral and cellmediated immunity, down-regulates the innate immune response to infection, as well as functioning as a T cell tolerogen and regulating the immune response to the intracellular nucleocapsid. A bioinformatics approach was used to show that the HBeAg and precursory genetic codes share remarkable sequence conservation in all mammalian-infecting hepadnaviruses, irrespective of host, genotype, or geographic origin. Whilst much of this sequence conservation was within key immunomodulatory epitopes, highest conservation was observed at the unique HBeAg N-terminus, suggesting this sequence in particular may play an important role in HBeAg function. © 2009 Wiley-Liss, Inc.
Authors & Co-Authors
Revill, Peter A.
Australia
Victorian Infectious Diseases Reference Laboratory
Yuen, Lilly
Australia
Victorian Infectious Diseases Reference Laboratory
Walsh, Renae
Australia
Victorian Infectious Diseases Reference Laboratory
Perrault, Marie
Australia
Victorian Infectious Diseases Reference Laboratory
France, Lyon
Université de Lyon
Locarnini, Stephen A.
Australia
Victorian Infectious Diseases Reference Laboratory
Kramvis, Anna
South Africa, Johannesburg
University of the Witwatersrand
Statistics
Citations: 37
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1002/jmv.21645
ISSN:
01466615
e-ISSN:
10969071
Research Areas
Genetics And Genomics
Infectious Diseases