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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Benzophenone C-glucosides and gallotannins from mango tree stem bark with broad-spectrum anti-viral activity
Bioorganic and Medicinal Chemistry, Volume 22, No. 7, Year 2014
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Description
The high mutation rate of RNA viruses has resulted in limitation of vaccine effectiveness and increased emergence of drug-resistant viruses. New effective antivirals are therefore needed to control of the highly mutative RNA viruses. The n-butanol fraction of the stem bark of Mangifera indica exhibited inhibitory activity against influenza neuraminidase (NA) and coxsackie virus 3C protease. Bioassay guided phytochemical study of M. indica stem bark afforded two new compounds including one benzophenone C-glycoside (4) and one xanthone dimer (7), together with eleven known compounds. The structures of these isolated compounds were elucidated on the basis of spectroscopic evidences and correlated with known compounds. Anti-influenza and anti-coxsackie virus activities were evaluated by determining the inhibition of anti-influenza neuraminidase (NA) from pandemic A/RI/5+/1957 H2N2 influenza A virus and inhibition of coxsackie B3 virus 3C protease, respectively. The highest anti-influenza activity was observed for compounds 8 and 9 with IC50 values of 11.9 and 9.2 μM, respectively. Compounds 8 and 9 were even more potent against coxsackie B3 virus 3C protease, with IC50 values of 1.1 and 2.0 μM, respectively. Compounds 8 and 9 showed weak cytotoxic effect against human hepatocellular carcinoma and human epithelial carcinoma cell lines through MTT assay. © 2014 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Abdel-Mageed, Wael M.
Unknown Affiliation
Bayoumi, Soad Abdel Latief Hassan
Unknown Affiliation
Chen, Caixia
Unknown Affiliation
Vavricka, Christopher J.
Unknown Affiliation
Li, Li
Unknown Affiliation
Malik, Ajamaluddin
Unknown Affiliation
Dai, Huanqin
Unknown Affiliation
Song, Fuhang
Unknown Affiliation
Wang, Luoqiang
Unknown Affiliation
Zhang, Jingyu
Unknown Affiliation
Gao, George Fu
Unknown Affiliation
Lv, Yali
Unknown Affiliation
Liu, Lihong
Unknown Affiliation
Liu, Xueting
Unknown Affiliation
Sayed, Hanaa Mohamed
Unknown Affiliation
Zhang, Lixin
Unknown Affiliation
Statistics
Citations: 32
Authors: 16
Affiliations: 7
Identifiers
Doi:
10.1016/j.bmc.2014.02.014
ISSN:
09680896
e-ISSN:
14643391
Research Areas
Cancer