Antiradical, antimicrobial and enzyme inhibition evaluation of sulfonamide derived esters; synthesis, X-Ray analysis and DFT studies

Two carboxylate esters (methyl: (I) and ethyl: (II)) of 4-{(4-methylphenylsulfonamido)- methyl}cyclohexanecarboxylic acid (sulfonamide) were synthesized and characterized by FTIR and X-ray crystallography. DFT studies were conducted in order to optimize the structures using Gaussian software which confirmed the bond angels and bond lengths obtained from single crystal analysis. Both Compounds (I and II) were evaluated for their biological studies viz; antioxidant activity (DPPH), enzyme inhibition activity (esterase and proteases), antibacterial (Halomonas halophila, Halomonas salina, Shigella sonnei, Bacillus subtilis, Chromohalobacter salexigens, Chromohalobacter israelensis, Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae) and anti-fungal (Aspergillus niger and Alternaria alternata). Results depicted that II is more active as compared to I in antioxidant and esterases while I is more potent against protease while moderate results were shown by both.