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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The N-terminal domain of Plasmodium falciparum circumsporozoite protein represents a target of protective immunity
Vaccine, Volume 27, No. 2, Year 2009
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Description
The N-terminal domain of the circumsporozoite protein (CSP) has been largely neglected in the search for a malaria vaccine in spite of being a target of inhibitory antibodies and protective T cell responses in mice. Thus, in order to develop this region as a vaccine candidate to be eventually associated with other candidates and, in particular, with the very advanced C-terminal counterpart, synthetic constructs representing N- and C-terminal regions of Plasmodium falciparum and Plasmodium berghei CSP were administered as single or combined formulations in mice. We show that the antisera generated against the combinations inhibit sporozoite invasion of hepatocytes in vitro better than antisera against single peptides. Furthermore, two different P. falciparum CSP N-terminal constructs (PfCS22-110 and PfCS65-110) were recognized by serum samples from people living in malaria-endemic regions. Importantly, recognition of the short N-terminal peptide (PfCS65-110) by sera from children living in a malaria-endemic region was associated with protection from disease. Taken together, these results underline the potential of using such fragments as malaria vaccine candidates. © 2008 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Bongfen, Silayuv E.
Switzerland, Lausanne
Université de Lausanne Unil
Ntsama, Patricia M.
Switzerland, Lausanne
Université de Lausanne Unil
Offner, Sandra
Switzerland, Lausanne
Université de Lausanne Unil
Smith, Thomas A.
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Felger, Ingrid
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Tanner, Marcel
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Alonso, Pedro Luís
Spain, Barcelona
Hospital Clinic Barcelona
Nèbiè, Issa O.
Burkina Faso, Ouagadougou
Centre National de Recherche et de Formation Sur le Paludisme
Romero, Jackeline F.
Switzerland, Lausanne
Université de Lausanne Unil
Silvie, Olivier
Germany, Heidelberg
Medizinischen Fakultät Heidelberg
Torgler, Ralph
Switzerland, Lausanne
Université de Lausanne Unil
Corradin, Giampietro
Switzerland, Lausanne
Université de Lausanne Unil
Statistics
Citations: 83
Authors: 12
Affiliations: 5
Identifiers
Doi:
10.1016/j.vaccine.2008.09.097
ISSN:
0264410X
Research Areas
Infectious Diseases
Maternal And Child Health